This proposal represents a competitive renewal of the Boston University Multidisciplinary Clinical Research Center grant which was established in 2001 and built on a strong foundation of outstanding epidemiology and clinical research. The strong record of accomplishment in patient oriented medical research at Boston University has been not only maintained in the last four years but expanded. What we propose creates new directions and areas of research for this already productive group of investigators who work together closely, and it promises to produce further major insights into rheumatic disease causation and treatment. Led by Director, Dr. David Felson and Associate Director, Dr. Saralynn Allaire, this group of full-time MCRC investigators who work together in shared office space will meet weekly in Methodology Core group meetings to discuss and review both projects proposed here and other funded and non-funded clinical research. This Core will provide support for the proposed projects: """"""""Bracing in Patellofemoral Osteoarthritis: A Clinical Trial"""""""", David J. Hunter, PI, """"""""Risk Factors for Gout Attacks: A Case-crossover Study"""""""", Yuqing Zhang, PI, """"""""Interplay of Thrombosis and Inflammation in Vasculitis"""""""", Peter Merkel, PI. An administrative unit will provide oversight to ensure that these projects are successfully accomplished and that core resources for support of these and other projects are allocated efficiently.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-YZW-E (O1))
Program Officer
Lester, Gayle E
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Boston University
Internal Medicine/Medicine
Schools of Medicine
United States
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Jafarzadeh, S Reza; Felson, David T (2018) Updated Estimates Suggest a Much Higher Prevalence of Arthritis in United States Adults Than Previous Ones. Arthritis Rheumatol 70:185-192
Jorge, April M; Lu, Na; Keller, Sarah F et al. (2018) The Effect of Statin Use on Mortality in Systemic Autoimmune Rheumatic Diseases. J Rheumatol 45:1689-1695
Jorge, April M; Lu, Na; Zhang, Yuqing et al. (2018) Unchanging premature mortality trends in systemic lupus erythematosus: a general population-based study (1999-2014). Rheumatology (Oxford) 57:337-344
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Vargas-Santos, Ana Beatriz; Peloquin, Christine E; Zhang, Yuqing et al. (2018) Association of Chronic Kidney Disease With Allopurinol Use in Gout Treatment. JAMA Intern Med 178:1526-1533
Nguyen, Uyen-Sa D T; Zhang, Yuqing; Lu, Na et al. (2018) Smoking paradox in the development of psoriatic arthritis among patients with psoriasis: a population-based study. Ann Rheum Dis 77:119-123
Jorge, April M; Melles, Ronald B; Zhang, Yuqing et al. (2018) Hydroxychloroquine prescription trends and predictors for excess dosing per recent ophthalmology guidelines. Arthritis Res Ther 20:133
Jinno, Sadao; Lu, Na; Jafarzadeh, S Reza et al. (2018) Trends in Hospitalizations for Serious Infections in Patients With Rheumatoid Arthritis in the US Between 1993 and 2013. Arthritis Care Res (Hoboken) 70:652-658
Keller, Sarah F; Rai, Sharan K; Lu, Na et al. (2018) Statin use and mortality in gout: A general population-based cohort study. Semin Arthritis Rheum 48:449-455

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