The overall objective of the Methodology Core is to provide access to innovative methodological expertise in biostatistics, outcomes and clinical research and along with computational resources necessary for the successful completion of the proposed MCRC projects and other important projects within the research base. The Core also provides an educational resource with the intent of enhancing the methodological quality of research initiatives in musculoskeletal diseases at Dartmouth.
The specific aims are 1) to facilitate the implementation and completion of all MCRC projects and to assist investigators within the research base by providing expertise in biostatistics, research design, outcomes research, data management, and advanced computing, 2) to provide access to specialized data bases and computing resources, 3) to establish a targeted educational forum to foster methodological expertise within the existing research base by conducting research-in progress seminars in multidisciplinary clinical research with a focus on musculoskeletal disease, specialized seminars and directed research courses for pre- and post-doctoral trainees in the academic programs represented within the research base, and methodological mentorship for advanced trainees in graduate and post-graduate programs affiliated with the MCRC, 4) to provide methodological support for research review and data and safety monitoring for MCRC projects, and 5) to promote methodologic research in issues critical to the advancement of specific areas within the research base. The Core is highly integrated and closely aligned with quantitative and educational resources throughout Dartmouth, allowing for a broader representation and mutual sharing of expertise across the institution.

Public Health Relevance

Dartmouth has many experienced investigators and sources of data that will be used to improve health for individuals with musculoskeletal disease. By expanding a unique national research program in musculoskeletal diseases, this grant will train new researchers and provide high-quality resources for research projects addressing health,care in those who have broken a bone, decision making about back surgery, and the safety of new medical devices.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAR1-KM (M1))
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Dartmouth College
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Marfeo, Elizabeth E; Ni, Pengsheng; McDonough, Christine et al. (2018) Improving Assessment of Work Related Mental Health Function Using the Work Disability Functional Assessment Battery (WD-FAB). J Occup Rehabil 28:190-199
Moulton, Haley; Tosteson, Tor D; Zhao, Wenyan et al. (2018) Considering Spine Surgery: A Web-Based Calculator for Communicating Estimates of Personalized Treatment Outcomes. Spine (Phila Pa 1976) 43:1731-1738
Abdu, William A; Sacks, Olivia A; Tosteson, Anna N A et al. (2018) Long-Term Results of Surgery Compared With Nonoperative Treatment for Lumbar Degenerative Spondylolisthesis in the Spine Patient Outcomes Research Trial (SPORT). Spine (Phila Pa 1976) 43:1619-1630
Klare, Christian M; Fortney, Thomas A; Kahng, Peter W et al. (2018) Prognostic Factors for Success After Irrigation and Debridement With Modular Component Exchange for Infected Total Knee Arthroplasty. J Arthroplasty 33:2240-2245
Tapp, Stephanie J; Martin, Brook I; Tosteson, Tor D et al. (2018) Understanding the value of minimally invasive procedures for the treatment of lumbar spinal stenosis: the case of interspinous spacer devices. Spine J 18:584-592
Skolasky, Richard L; Scherer, Emily A; Wegener, Stephen T et al. (2018) Does reduction in sciatica symptoms precede improvement in disability and physical health among those treated surgically for intervertebral disc herniation? Analysis of temporal patterns in data from the Spine Patient Outcomes Research Trial. Spine J 18:1318-1324
Munson, J C; Bynum, J P W; Bell, J-E et al. (2018) Impact of prescription drugs on second fragility fractures among US Medicare patients. Osteoporos Int 29:2771-2779
Martin, Brook I; Lurie, Jon D; Farrokhi, Farrokh R et al. (2018) Early Effects of Medicare's Bundled Payment for Care Improvement Program for Lumbar Fusion. Spine (Phila Pa 1976) 43:705-711
Passias, Peter G; Poorman, Gregory; Lurie, Jon et al. (2018) Patient Profiling Can Identify Spondylolisthesis Patients at Risk for Conversion from Nonoperative to Operative Treatment. JB JS Open Access 3:e0051
Abdu, Robert W; Abdu, William A; Pearson, Adam M et al. (2017) Reoperation for Recurrent Intervertebral Disc Herniation in the Spine Patient Outcomes Research Trial: Analysis of Rate, Risk Factors, and Outcome. Spine (Phila Pa 1976) 42:1106-1114

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