The overarching goal of the Administrative Core of the Northwestern University (NU) MCRC is to provide a structure that will optimize the function of the Center. This Core will be responsible for the overall direction, organization, operation, and integration of the MCRC. We have organized this goal in 6 specific aims: 1) provide a) the structure for this proposal (the NU MCRC renewal application) that best presents the science and logistics of the work proposed and b) the structure for the conduct of the studies to ensure their progress and full fruition; 2) provide the administrative structure that will sustain effective and efficient day-today operation of the MCRC; 3) provide the scientific expertise and leadership to identify projects concerning issues relevant to persons with or at risk for rheumatic diseases, and harness the Center to help them to develop and advance; 4) sustain optimal communication, cooperation, and collaboration among MCRC investigators as well as scientists in related fields at our institution and elsewhere; 5) expand the influence of the MCRC within our institution and identify and secure institutional support to promote and enhance the activities of our Center; and 6) ensure that a data sharing plan is implemented by each component of the Center, In the Administrative Core Proposal, we lay out the approach to achieve each specific aim. The Administrative Core is housed in the Division of Rheumatology and includes: the MCRC director. Dr. Leena Sharma; associate directors Drs. Richard Pope and Rosalind Ramsey-Goldman; the Methodology/Data Management Core director. Dr. Rowland Chang; Research Administrator Ms. Anabel Garza; and Division Administrator Ms. Christine De Luca. The proposed new cycle of the NU MCRC wi'll have 3 levels of advisory support: the Executive Committee (internal, day-to-day operations); the Oversight Committee (internal, oversight by the NU Feinberg School of Medicine and relevant department leaders); and the External Advisory Committee. The Executive Committee will bear ultimate responsibility for achievement of the specific aims; this committee includes Drs. Leena Sharma, Richard Pope, Rosalind- Ramsey Goldman, Rowland Chang, Joan Chmiel, Lauren Pachman, W. Zev Rymer, Thomas Schnitzer, and Justin Starren. Each member brings a unique background, providing multidisciplinary scrutiny of each issue.

Public Health Relevance

The Administrative Core of the Northwestern University (NU) MCRC has led the organization and development of this proposal and will be responsible for these same tasks in the proposed new cycle of our Center. The mission of this Core is to provide a structure - both in the day-to-day operations and in the larger vision - that will optimize the functioning, productivity, and growth of the MCRC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
4P60AR064464-04
Application #
9116771
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Program Officer
Lester, Gayle E
Project Start
2013-08-01
Project End
2018-07-31
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
4
Fiscal Year
2016
Total Cost
$976,222
Indirect Cost
$316,437
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Bernatsky, Sasha; Ramsey-Goldman, Rosalind; Petri, Michelle et al. (2018) Smoking Is the Most Significant Modifiable Lung Cancer Risk Factor in Systemic Lupus Erythematosus. J Rheumatol 45:393-396
Jayabalan, Prakash; Kocherginsky, Masha; Chang, Alison et al. (2018) Physical Activity and Worsening of Radiographic Findings in Persons With or at Higher Risk of Knee Osteoarthritis. Arthritis Care Res (Hoboken) :
Patel, Zubin; Lu, Xiaoming; Miller, Daniel et al. (2018) A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet :
Song, Jing; Chang, Alison H; Chang, Rowland W et al. (2018) Relationship of knee pain to time in moderate and light physical activities: Data from Osteoarthritis Initiative. Semin Arthritis Rheum 47:683-688
Mahieu, Mary A; Ahn, Grace E; Chmiel, Joan S et al. (2018) Serum adipokine levels and associations with patient-reported fatigue in systemic lupus erythematosus. Rheumatol Int 38:1053-1061
Hanly, John G; Li, Qiuju; Su, Li et al. (2018) Cerebrovascular Events in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study. Arthritis Care Res (Hoboken) 70:1478-1487
Barber, Megan R W; Hanly, John G; Su, Li et al. (2018) Economic Evaluation of Lupus Nephritis in the Systemic Lupus International Collaborating Clinics Inception Cohort Using a Multistate Model Approach. Arthritis Care Res (Hoboken) 70:1294-1302
Showalter, Kimberly; Hoffmann, Aileen; Rouleau, Gerald et al. (2018) Performance of Forced Vital Capacity and Lung Diffusion Cutpoints for Associated Radiographic Interstitial Lung Disease in Systemic Sclerosis. J Rheumatol 45:1572-1576
Pellegrini, Christine A; Ledford, Gwendolyn; Chang, Rowland W et al. (2018) Understanding barriers and facilitators to healthy eating and physical activity from patients either before and after knee arthroplasty. Disabil Rehabil 40:2004-2010
Gilbert, Abigail L; Lee, Jungwha; Ehrlich-Jones, Linda et al. (2018) A randomized trial of a motivational interviewing intervention to increase lifestyle physical activity and improve self-reported function in adults with arthritis. Semin Arthritis Rheum 47:732-740

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