There are three major goals in the Animal Neurobiological Core:1. To provide the environment, expertise and equipment necessary to accomplish each Specific Aim ofProjects 1 and 2 of this competitive renewal application for our NIH-NIDA Research Center.2. To provide the expertise and equipment, where necessary, to nurture Pilot Projects that involve tissuesfrom animals at a specific time in the stages of drug exposure, withdrawal or re-exposure.3. To provide training in studies involving animals exposed to drugs, withdrawn or re-exposed. The trainingmay include some or all aspects of animal study: the ethical issues of research with animals, the handling ofspecific rodent species and drug administration; behavioral monitoring of loeomotor activity; specificbehavioral tests such as the development of conditioned place preference or elevated plus maze; theanalysis of behaviors such as stereotypy after the administration of the psychostimulant cocaine; details ofsmall animal surgery; techniques of microdialysis in specific regions of the rodent brain; the techniques ofmonitoring self-administration of heroin or cocaine in both the mouse and the rat; the preparation of protocolsfor submission to the Institutional Animal Care and Use Committee of the Rockefeller University.
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