There are three major goals in the Animal Neurobiological Core: 1. To provide the environment, expertise and equipment necessary to accomplish each Specific Aim of Projects 1 and 2 of this competitive renewal application for our NIH-NIDA Research Center. 2. To provide the expertise and equipment, where necessary, to nurture Pilot Projects that involve tissues from animals at a specific time in the stages of drug exposure, withdrawal or re-exposure. 3. To provide training in studies involving animals exposed to drugs, withdrawn or re-exposed. The training may include some or all aspects of animal study: the ethical issues of research with animals, the handling of specific rodent species and drug administration;behavioral monitoring of loeomotor activity;specific behavioral tests such as the development of conditioned place preference or elevated plus maze;the analysis of behaviors such as stereotypy after the administration of the psychostimulant cocaine;details of small animal surgery;techniques of microdialysis in specific regions of the rodent brain;the techniques of monitoring self-administration of heroin or cocaine in both the mouse and the rat;the preparation of protocols for submission to the Institutional Animal Care and Use Committee of the Rockefeller University.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Comprehensive Center (P60)
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Special Emphasis Panel (ZDA1)
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Rockefeller University
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Gasser, Paul J; Hurley, Matthew M; Chan, June et al. (2017) Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice. Brain Struct Funct 222:1913-1928
Butelman, Eduardo Roque; Bacciardi, Silvia; Maremmani, Angelo Giovanni Icro et al. (2017) Can a rapid measure of self-exposure to drugs of abuse provide dimensional information on depression comorbidity? Am J Addict 26:632-639
Valenza, Marta; Picetti, Roberto; Yuferov, Vadim et al. (2016) Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration. Neuropharmacology 105:639-650
Garzón, Miguel; Pickel, Virginia M (2016) Electron microscopic localization of M2-muscarinic receptors in cholinergic and noncholinergic neurons of the laterodorsal tegmental and pedunculopontine nuclei of the rat mesopontine tegmentum. J Comp Neurol 524:3084-103
Zhou, Yan; Leri, Francesco; Cummins, Erin et al. (2015) Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in rats. Physiol Behav 139:127-35
Zhou, Y; Kreek, M J (2015) Persistent increases in rat hypothalamic POMC gene expression following chronic withdrawal from chronic ""binge"" pattern escalating-dose, but not steady-dose, cocaine. Neuroscience 289:63-70
Zhou, Yan; Kreek, Mary Jeanne (2014) Alcohol: a stimulant activating brain stress responsive systems with persistent neuroadaptation. Neuropharmacology 87:51-8
Mayer-Blackwell, B; Schlussman, S D; Butelman, E R et al. (2014) Self administration of oxycodone by adolescent and adult mice affects striatal neurotransmitter receptor gene expression. Neuroscience 258:280-91
Proudnikov, Dmitri; Randesi, Matthew; Levran, Orna et al. (2013) Polymorphisms of the kappa opioid receptor and prodynorphin genes: HIV risk and HIV natural history. J Acquir Immune Defic Syndr 63:17-26
Schlussman, S D; Buonora, M; Brownstein, A J et al. (2013) Regional mRNA expression of GABAergic receptor subunits in brains of C57BL/6J and 129P3/J mice: strain and heroin effects. Brain Res 1523:49-58

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