The objective of this proposal is to expand a family study of adolescent boys who experience severe substance dependence/abuse and conduct disorder. In this application we propose to evaluate an additional 200 patient probands (100 male probands and 100 female probands) and their families. An important strength of the controlled family study design proposed is that, in addition to the highly selected treatment families, we will also evaluate 200 control families, matched to the patient probands by gender, age, ethnicity, and zip code of residence. The oversampling of highly selected treatment families, in combination with unselected control families, provides a powerful analytical design for understanding the familial aggregation and transmission of substance use disorders (SUD) and comorbid psychopathology in the population. These new data will double the size of the original family study of 200 male probands and their families and 200 control families currently in progress, allowing us to move beyond descriptive models to the investigation of underlying mechanisms and mediating variables in SUD. The inclusion of female patient probands will provide an important addition to the original study, enabling us to address critical issues concerning the generalizability of findings to female populations. In addition, the current study has been designed to interface not only with the original study, but also with the adoption study (Research Component 3) and twin study (Research Component 4) components of this Center Grant. Use of the same core of assessment instruments across these components will provide data that can be used jointly in analyses to decompose familial influences into genetic effects and family environmental components. Further, comparisons among the population twin sample, the adoption study families, and the control families in the current study will provide valuable tests of the generalizability of results across three distinct behavioral genetic designs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Comprehensive Center (P60)
Project #
1P60DA011015-01
Application #
6238069
Study Section
Project Start
1997-08-01
Project End
1998-06-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
du Pont, Alta; Rhee, Soo Hyun; Corley, Robin P et al. (2018) Rumination and Psychopathology: Are Anger and Depressive Rumination Differentially Associated with Internalizing and Externalizing Psychopathology? Clin Psychol Sci 6:18-31
Curry, Inga; Luk, Jeremy W; Trim, Ryan S et al. (2018) Impulsivity Dimensions and Risky Sex Behaviors in an At-Risk Young Adult Sample. Arch Sex Behav 47:529-536
Rhee, Soo Hyun; Friedman, Naomi P; Smith Watts, Ashley K et al. (2018) The Association Between Toddlerhood Self-Control and Later Externalizing Problems. Behav Genet 48:125-134
Huggett, Spencer B; Hatoum, Alexander S; Hewitt, John K et al. (2018) The Speed of Progression to Tobacco and Alcohol Dependence: A Twin Study. Behav Genet 48:109-124
Curry, Inga; Trim, Ryan S; Brown, Sandra A et al. (2018) Positive expectancies mediate the association between sensation seeking and marijuana outcomes in at-risk young adults: A test of the acquired preparedness model. Am J Addict :
Friedman, Naomi P; du Pont, Alta; Corley, Robin P et al. (2018) Longitudinal Relations Between Depressive Symptoms and Executive Functions From Adolescence to Early Adulthood: A Twin Study. Clin Psychol Sci 6:543-560
Yokoyama, Yoshie; Jelenkovic, Aline; Hur, Yoon-Mi et al. (2018) Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts. Int J Epidemiol 47:1195-1206
Al-Tayyib, Alia; Riggs, Paula; Mikulich-Gilbertson, Susan et al. (2018) Prevalence of Nonmedical Use of Prescription Opioids and Association With Co-occurring Substance Use Disorders Among Adolescents in Substance Use Treatment. J Adolesc Health 62:241-244
Ellingson, Jarrod M; Corley, Robin; Hewitt, John K et al. (2018) A prospective study of alcohol involvement and the dual-systems model of adolescent risk-taking during late adolescence and emerging adulthood. Addiction :
Piirtola, Maarit; Jelenkovic, Aline; Latvala, Antti et al. (2018) Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts. PLoS One 13:e0200140

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