The cochlear nucleus is the terminus for all incoming auditory information to the brain and the origin of all central auditory pathways. In a general way, the role of the cochlear nucleus is to recode signals from the auditory nerve and to distribute the resultant messages to higher centers. The long term goal of this research is to understand the structural basis by which neural activity from the auditory nerve is """"""""processed"""""""" in the cochlear nucleus. This effort requires a thorough knowledge of the synaptic organization in the cochlear nucleus because the coding process is hypothesized to be dependent on definable features of the relationship between pre- and postsynaptic neurons. The present proposal will apply intracellular recording and staining methods to reveal the structural and functional character of individual neurons, tract-tracing methods to reveal the source and distribution of input projections, and immunocytochemical techniques to identify molecules associated with neurotransmitter cell classes. These data will have direct relevance to ideas about excitation and inhibition in the cochlear nucleus and about how neural circuits act to shape the coding process.

Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Rothman, Jason S; Manis, Paul B (2003) The roles potassium currents play in regulating the electrical activity of ventral cochlear nucleus neurons. J Neurophysiol 89:3097-113

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