This is an application to establish an Oral Cancer Center at the University of Pittsburgh within the overall program of the Comprehensive Oral Health Research Center of Discovery The University of Pittsburgh already has in place substantial resources, capabilities, innovative research and clinical activities with direct relevance to cancer of the oral cavity, which includes the School of Medicine, the School of Dental Medicine, the Graduate School of Public Health, the University of Pittsburgh Medical Center Health System, and the University of Pittsburgh Cancer Institute. Using these resources. the proposed Oral Cancer Center will focus research and clinical efforts on oral cancer and will aim to develop a broad-based comprehensive program integrating biomedical, behavioral, social and clinical services as well as basic re research in oral cancer. The overall objectives of the Center are to coordinate and encourage multi-disciplinary collaborations within a large pool of existing expertise in oral cancer. Improvement in the clinical care of patients with oral cavity cancer is highly dependent upon scientific investigations and on rapid translation of research findings into novel clinical trials to improve the cure rate in oral cavity cancer. The Oral Cancer Center will foster basic and clinical research, as exemplified by the four major programs. Molecular Carcinogenesis and Cell Biology. Oral Immunology; Prevention and Control; and Clinical Investigations, which will encompass the scope of research at the Center. Within the programs are five research and one pilot proposals included in this application. Fie Cores will provide support for the Center's research and clinical activities. To ensure the availability of high quality preention, control, early detection, and education programs in oral cancer in Western Pennsylvania, the Oral Cancer Center will implement and expand community outreach activities and develop methods to improve education of health care professionals. Increased awareness of risk factors for oral cancer among health care providers and the public are likely to make an impact on prevention and early detection of oral cavity cancer. The overall goal of the Oral Cancer Center at the University of Pittsburgh is to make a substantial impact on decreasing morbidity and mortality from oral cavity cancer in Western Pennsylvania.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Comprehensive Center (P60)
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Special Emphasis Panel (ZDE1-YS (10))
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Sandberg, Ann
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University of Pittsburgh
Schools of Medicine
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Sobo-Vujanovic, Andrea; Munich, Stephan; Vujanovic, Nikola L (2014) Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells. Cell Immunol 289:119-27
Baskic, Dejan; Vujanovic, Lazar; Arsenijevic, Nebojsa et al. (2013) Suppression of natural killer-cell and dendritic-cell apoptotic tumoricidal activity in patients with head and neck cancer. Head Neck 35:388-98
Wan, Xiao Chloe; Egloff, Ann Marie; Johnson, Jonas (2012) Histological assessment of cervical lymph node identifies patients with head and neck squamous cell carcinoma (HNSCC): who would benefit from chemoradiation after surgery? Laryngoscope 122:2712-22
Zhong, Shilong; Nukui, Tomoko; Buch, Shama et al. (2011) Effects of ERCC2 Lys751Gln (A35931C) and CCND1 (G870A) polymorphism on outcome of advanced-stage squamous cell carcinoma of the head and neck are treatment dependent. Cancer Epidemiol Biomarkers Prev 20:2429-37
Ge, Lisheng; Baskic, Dejan; Basse, Per et al. (2009) Sheddase activity of tumor necrosis factor-alpha converting enzyme is increased and prognostically valuable in head and neck cancer. Cancer Epidemiol Biomarkers Prev 18:2913-22
Martin, Christa Lese; Reshmi, Shalini C; Ried, Thomas et al. (2008) Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature. Oral Oncol 44:369-82
Buch, Shama C; Nazar-Stewart, Valle; Weissfeld, Joel L et al. (2008) Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes. Head Neck 30:1139-47
White, Jason S; Weissfeld, Joel L; Ragin, Camille C R et al. (2007) The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines. Oral Oncol 43:701-12
Xu, Jun; Chakrabarti, Ayan K; Tan, Jennifer L et al. (2007) Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Blood 109:3333-41
Makarenkova, Valeria; Chakrabarti, Ayan K; Liberatore, Jennifer A et al. (2005) Dendritic cells and natural killer cells interact via multiple TNF family molecules. J Leukoc Biol 77:408-13

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