Abstract

This study is designed to examine the relationships of risk factors for children with non-syndromic cleft lip and palate (CL&P) to psychological adjustment. The objective is to determine which risk factors have a primary influence on the behavioral inhibition or shyness seen in many children with CL&P.
The specific aims are to determine how facial appearance and speech contribute to behavioral adjustment and how other individual characteristics such as verbal expression deficit and auditory memory deficits may affect the relationship. Also, it is planned to perform a behavioral analysis and intervention to determine if excessive behavioral inhibition occurs in all situations and whether it is modifiable. The analyses will compare children with CL&P, who have different forms of behavioral inhibition and determine if differences are related to the risk factors. Predictive equations will determine how much early characteristics of verbal disability or memory deficit versus speech and facial appearance contributes to behavior inhibition and possible anxiety.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Comprehensive Center (P60)
Project #
5P60DE013076-05
Application #
6784265
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2003
Total Cost
$86,977
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Haworth, Simon; Shungin, Dmitry; van der Tas, Justin T et al. (2018) Consortium-based genome-wide meta-analysis for childhood dental caries traits. Hum Mol Genet 27:3113-3127
Govil, Manika; Mukhopadhyay, Nandita; Weeks, Daniel E et al. (2018) Novel caries loci in children and adults implicated by genome-wide analysis of families. BMC Oral Health 18:98
Yang, Jie; Zhu, Wei; Chen, Jiansong et al. (2014) Genome-wide two-marker linkage disequilibrium mapping of quantitative trait loci. BMC Genet 15:20
Beaty, T H; Taub, M A; Scott, A F et al. (2013) Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. Hum Genet 132:771-81
Skare, Oivind; Jugessur, Astanand; Lie, Rolv Terje et al. (2012) Application of a novel hybrid study design to explore gene-environment interactions in orofacial clefts. Ann Hum Genet 76:221-36
Wehby, G L; Tyler, M C; Lindgren, S et al. (2012) Oral clefts and behavioral health of young children. Oral Dis 18:74-84
Shaffer, J R; Wang, X; Feingold, E et al. (2011) Genome-wide association scan for childhood caries implicates novel genes. J Dent Res 90:1457-62
Schneider, Galen B; Zaharias, Rebecca; Seabold, Denise et al. (2011) Integrin-associated tyrosine kinase FAK affects Cbfa1 expression. J Orthop Res 29:1443-7
Larjava, H; Koivisto, L; Häkkinen, L et al. (2011) Epithelial integrins with special reference to oral epithelia. J Dent Res 90:1367-76
Jugessur, Astanand; Shi, Min; Gjessing, Håkon Kristian et al. (2010) Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. PLoS One 5:e11493

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