The primary goal of this Animal Core is to develop new mouse models of craniofacial and dentition disorders as a resource to the scientific community. We will also collaborate with other investigators in this disorders as a resource to the scientific community. We will also collaborate with other investigators in this Comprehensive Oral Health Research Center of Discovery (COHRCD) to enhance the mouse model aspects of the COHRCD. We will discover and characterize (genetically and phenotypically) new spontaneous mouse mutations to provide the scientific community with model systems for research on facial and skull development and for models of specific human craniofacial syndromes. We will collaborate with other investigators in the COHRCD to provide additional expertise on the mouse (Projects II and III), compare phenotypes of new mutant mice with human disorders (Clinical Core), and announce newly developed mutants for the Center web page (Education/Informatics Core). Mice carrying mutations that alter developmental pathways or metabolic functions provide model systems for analyzing the defects in comparable human disorders and for testing methods of therapeutic intervention. Spontaneous mouse mutations are identified on the basis of a biomedically relevant phenotype and can lead to the discovery of novel gens involved in craniofacial and dental development and morphology. Mutant mice from the strains will be distributed to the scientific community on a fee-for-mice basis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Comprehensive Center (P60)
Project #
5P60DE013078-03
Application #
6481908
Study Section
Project Start
2001-08-01
Project End
2002-07-31
Budget Start
Budget End
Support Year
3
Fiscal Year
2001
Total Cost
$254,104
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Richtsmeier, Joan T (2018) A century of development. Am J Phys Anthropol 165:726-740
Taub, Margaret A; Schwender, Holger; Beaty, Terri H et al. (2012) Incorporating genotype uncertainties into the genotypic TDT for main effects and gene-environment interactions. Genet Epidemiol 36:225-34
Ludwig, Kerstin U; Mangold, Elisabeth; Herms, Stefan et al. (2012) Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet 44:968-71
Hill, Cheryl A; Vaddi, S; Moffitt, Amanda et al. (2011) Intracranial volume and whole brain volume in infants with unicoronal craniosynostosis. Cleft Palate Craniofac J 48:394-8
Aldridge, Kristina (2011) Patterns of differences in brain morphology in humans as compared to extant apes. J Hum Evol 60:94-105
Richtsmeier, J T; Deleon, V B (2009) Morphological integration of the skull in craniofacial anomalies. Orthod Craniofac Res 12:149-58
Frazier, Brenda C; Mooney, Mark P; Losken, H Wolfgang et al. (2008) Comparison of craniofacial phenotype in craniosynostotic rabbits treated with anti-Tgf-beta2 at suturectomy site. Cleft Palate Craniofac J 45:571-82
Park, Ji Wan; McIntosh, Iain; Hetmanski, Jacqueline B et al. (2007) Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations. Genet Med 9:219-27
Parsons, Trish; Ryan, Timothy M; Reeves, Roger H et al. (2007) Microstructure of trabecular bone in a mouse model for Down syndrome. Anat Rec (Hoboken) 290:414-21
Mooney, Mark P; Losken, H Wolfgang; Moursi, Amr M et al. (2007) Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits. J Craniofac Surg 18:336-46;discussion 347-9

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