Core - Molecular

Scott, Alan L.

Abstract

The Molecular and Technology TRANSFER Core will provide Center for Craniofacial Development and Disorders. Investigators with access to modern molecular genetics services including DNA synthesis, DNA sequencing, mutation detection, DNA isolation, cell culture, lymphocyte transformation, cryopreservation, physical mapping regents and specific YAC clones. This core will also assist investigators evaluate technologies developed in their studies for commercial licensing and patentability. The Molecular and Technology Transfer Core will provide reagents and services for the Clinical ore and Projects I, II, V, VI and VII. It will also advise Projects I and II involved in animal models; Projects III and VI concerned with therapeutics for craniosynostosis; Projects V, VI and VII developing DNA diagnostic testing; and Project VIII regarding behavioral and psychological services. This Core will monitor and enhance the ability of the Center to develop potentially marketable products and other effective interventions.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Dental & Craniofacial Research (NIDCR)
• Type: Comprehensive Center (P60)
• Project #: 5P60DE013078-05
• Application #: 6765349
• Support Year: 5
• Fiscal Year: 2003
• Total Cost: $254,104

Institution

• Name: Johns Hopkins University
• DUNS #: 001910777
• City: Baltimore
• State: MD
• Country: United States
• Zip Code: 21218

Publications

Richtsmeier, Joan T (2018) A century of development. Am J Phys Anthropol 165:726-740

Taub, Margaret A; Schwender, Holger; Beaty, Terri H et al. (2012) Incorporating genotype uncertainties into the genotypic TDT for main effects and gene-environment interactions. Genet Epidemiol 36:225-34

Ludwig, Kerstin U; Mangold, Elisabeth; Herms, Stefan et al. (2012) Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet 44:968-71

Hill, Cheryl A; Vaddi, S; Moffitt, Amanda et al. (2011) Intracranial volume and whole brain volume in infants with unicoronal craniosynostosis. Cleft Palate Craniofac J 48:394-8

Aldridge, Kristina (2011) Patterns of differences in brain morphology in humans as compared to extant apes. J Hum Evol 60:94-105

Richtsmeier, J T; Deleon, V B (2009) Morphological integration of the skull in craniofacial anomalies. Orthod Craniofac Res 12:149-58

Frazier, Brenda C; Mooney, Mark P; Losken, H Wolfgang et al. (2008) Comparison of craniofacial phenotype in craniosynostotic rabbits treated with anti-Tgf-beta2 at suturectomy site. Cleft Palate Craniofac J 45:571-82

Park, Ji Wan; McIntosh, Iain; Hetmanski, Jacqueline B et al. (2007) Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations. Genet Med 9:219-27

Parsons, Trish; Ryan, Timothy M; Reeves, Roger H et al. (2007) Microstructure of trabecular bone in a mouse model for Down syndrome. Anat Rec (Hoboken) 290:414-21

Mooney, Mark P; Losken, H Wolfgang; Moursi, Amr M et al. (2007) Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits. J Craniofac Surg 18:336-46;discussion 347-9