The ultimate value of fundamental biological discoveries from the Center for Inflammatory Disorders will become apparent only when """"""""downstream"""""""" interventions are implemented to control inflammation, thereby improving the health of patients and population. In this context, human health includes both extension of lifespan and enhancement of Quality of Life (QoL)-two objectives of the health care system enshrined in the Healthy People 2000 initiative. However, it is only recently that reliable and valid methods for measuring oral health related QoL have become widely available, with the consequence that methods for evaluate quality of life outcomes from oral health interventions remain in their infancy. One area that is important to this Center's mission is the potential for synergistic effects of local (oral) and systemic disease on human health, although there is a lack of methodological work to evaluate such joint effects with either disease specific (ie. oral health related QoL) or generic QoL instruments.
The aim of this study is to evaluate methods that are optimal for measuring joint and synergistic effects on systemic conditions, oral disease and its treatment on quality of life. This study will measure oral health related QoL using the short form Oral Health Impact Profile (OHIP-14) and genetic QoL using the Medical Outcomes Study short-form health survey (SF-36). These questionnaires will be completed by 130 (terminal dentition) patients who have advanced dental disease and who have expressed an intent for ultimate removal of those teeth and placement with complete dentures. QoL measures will be administered at baseline, 4 weeks, 26 weeks and 52 weeks, and concurrent treatments and clinical status will be abstracted from treatment records. The data will be analyzed for psychometric independence of oral and generic QoL.
Specific aims will be explored initially through cross- sectional analyses, where QoL measures will be the dependent variables and oral status (aim 1) or dental treatments (aim 2) will be the dependent variables. our study hypotheses will then be analyzed using longitudinal data analyzed using repeated measures of variance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Comprehensive Center (P60)
Project #
5P60DE013079-02
Application #
6340842
Study Section
Project Start
2000-08-01
Project End
2001-07-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
$116,779
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Arce, R M; Caron, K M; Barros, S P et al. (2012) Toll-like receptor 4 mediates intrauterine growth restriction after systemic Campylobacter rectus infection in mice. Mol Oral Microbiol 27:373-81
Qian, Li; Wu, Hung-ming; Chen, Shih-Heng et al. (2011) ?2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway. J Immunol 186:4443-54
Arce, R M; Diaz, P I; Barros, S P et al. (2010) Characterization of the invasive and inflammatory traits of oral Campylobacter rectus in a murine model of fetoplacental growth restriction and in trophoblast cultures. J Reprod Immunol 84:145-53
Maile, Laura A; Busby, Walker H; Nichols, Timothy C et al. (2010) A monoclonal antibody against alphaVbeta3 integrin inhibits development of atherosclerotic lesions in diabetic pigs. Sci Transl Med 2:18ra11
Lemmon, Christopher A; Chen, Christopher S; Romer, Lewis H (2009) Cell traction forces direct fibronectin matrix assembly. Biophys J 96:729-38
Qian, Li; Hu, Xiaoming; Zhang, Dan et al. (2009) beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway. Glia 57:1600-9
Light, Kathleen C; Bragdon, Edith E; Grewen, Karen M et al. (2009) Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder. J Pain 10:542-52
Qian, Li; Wei, Sung-Jen; Zhang, Dan et al. (2008) Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia. J Immunol 181:660-8
Qian, Li; Flood, Patrick M (2008) Microglial cells and Parkinson's disease. Immunol Res 41:155-64
Williams, Ray C (2008) Understanding and managing periodontal diseases: a notable past, a promising future. J Periodontol 79:1552-9

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