The Prevention and Control (P&C) Core of the Einstein DRTC builds on its productive 32-year history by creating a new infrastnjcture of three functional units and by attracting faculty with community and psychosocial expertise and innovative methodologies. The interface and synergy among the functional units are crucial to the success of the P&C Core and the DRTC as a whole. The continuum of research designs creates many altematives for studying diabetes-related problems, all of which are focused on ameliorating health disparities. The primary mission of the Clinical Research Methodology Unit (CRMU) is to promote high-quality diabetes translational research, through consultation, training and mentoring in clinical research methods applicable to diabetes. Its objectives include: 1) to increase the quality and scope of diabetes related clinical trials, clinical physiology and translational research;and 2) to foster the career development of new diabetes clinical and translational investigators. The Behavioral Interventbn and Evaluation Methodology Unit (BIEM) facilitates the development and implementation of behavioral interventions and provides comprehensive evaluation support for research to prevent and control diabetes and its complications. Its objective include: 1) to increase the extent to which investigators develop effective interventions;and 2) to assist investigators to apply rigorous evaluation methods. Although the third unit of the P&C Core, the Social-Environmental Research Methodology (SERM) unit is new, it promotes our strengths in community and health disparities diabetes research. The objectives of tfiis proposed unit include: 1) to increase community and social capital development by providing expert resources for assessment and intervention, including community-based participatory research;and 2) to engage the community in diabetes-related research to reduce health disparities. The fonner objective will be provided by new faculty and resources;the latter will foster productivity through new collaborations at the community and public health agency levels. In summary, the Einstein P&C Core builds on its research strengths and its synergy with the DRTC as a whole, while enthusiastically supported by our medical school leadership.

Public Health Relevance

The P&C Core facilitates bridges from basic science and clinical research to epidemiology and applied effectiveness and translational research for broad implementation. It emphasizes dissemination and sustainability through its community engagement, focusing on the problems of minority populations that are particularly relevant in the Bronx, the poorest urban U.S. county, with diabetes prevalence up to 16.9%.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
5P60DK020541-35
Application #
8377571
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
35
Fiscal Year
2012
Total Cost
$312,930
Indirect Cost
$124,418
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Tang, Yan; Kwon, Hyokjoon; Neel, Brian A et al. (2018) The fructose-2,6-bisphosphatase TIGAR suppresses NF-?B signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC. J Biol Chem 293:7578-7591
Chemaly, Elie R; Troncone, Luca; Lebeche, Djamel (2018) SERCA control of cell death and survival. Cell Calcium 69:46-61
Iqbal, Niloy Jafar; Lu, Zhonglei; Liu, Shun Mei et al. (2018) Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity. JCI Insight 3:
Schloss, Jennifer; Ali, Riyasat; Racine, Jeremy J et al. (2018) HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression. J Immunol 200:3353-3363
Racine, Jeremy J; Stewart, Isabel; Ratiu, Jeremy et al. (2018) Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. Diabetes 67:923-935
Shu, Jun; Santulli, Gaetano (2018) Update on peripheral artery disease: Epidemiology and evidence-based facts. Atherosclerosis 275:379-381
Zhao, Xiaoping; Zhao, Li; Yang, Hao et al. (2018) Pyruvate kinase M2 interacts with nuclear sterol regulatory element-binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma. J Biol Chem 293:6623-6634
Qiu, Yunping; Moir, Robyn D; Willis, Ian M et al. (2018) Enhanced Isotopic Ratio Outlier Analysis (IROA) Peak Detection and Identification with Ultra-High Resolution GC-Orbitrap/MS: Potential Application for Investigation of Model Organism Metabolomes. Metabolites 8:
Liu, Shunmei; Marcelin, Genevieve; Blouet, Clemence et al. (2018) A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus. Mol Metab 8:37-50
Llewellyn, Sean R; Britton, Graham J; Contijoch, Eduardo J et al. (2018) Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice. Gastroenterology 154:1037-1046.e2

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