(taken from application): The guidelines for the Diabetes Research and Training Centers mandate a model demonstration unit (MDU) for the training of students and practitioners in diabetes care and for the support of diabetes research. The IU-DRTC has responded to this mandate by developing a multi-site MDU that addresses training and research in three diabetes patient populations: adults (with special emphasis on pregnant women with pre-existing and gestational diabetes), transitional age adolescents, and children. The primary goals of our multi-site MDU are to train health care professionals in state-of-the-art diabetes management and facilitate research that addresses barriers between what is thought to represent ideal diabetes care reflecting current scientific advances in the understanding of diabetes and what is routinely practiced. Even though there are distinct differences in patient populations served by the MDU, a unifying philosophy is involved in the demonstration of model diabetes care across all of these sites. Model care should: 1) be delivered by multi-disciplinary teams with an emphasis on interactive decision making, 2) incorporate algorithmic protocols that are based on state-of-the-art care standards, 3) be supported by new technologies when possible, and 4) be rigorously evaluated and revised as necessary. During the past cycle we have significantly expanded diabetes treatment programs in the MDU. As a result, trainees have exposure to all aspects of model diabetes care including state-of-the-art measures to improve glycemic control, formal weight management programs, and cardiovascular risk reduction programs. The programs afford trainees exposure to patients of all age groups (i.e., pediatrics, adolescents, adults and the elderly) and of varied ethnic and socioeconomic status. Furthermore, through exposure to the proposed Women?s Health Initiative MDU program, gender-specific aspects of providing care to females with diabetes will be modeled. Finally, an important expansion of our MDU are programs designed to provide training and education in model diabetes care to medical students, trainees, and primary care physicians who practice at sites distant from these state-of-the-art model programs. 2.The specific objectives of the IU-DRTC MDU are: 1.To establish state-of-the- art diabetes patient management programs for the demonstration of model care. 2.To train health professional students and practitioners in state-of-the-art management and education of persons with diabetes. 3.To serve as a resource to facilitate the conduct of biomedical, health care, educational, epidemiologic and psychosocial research in diabetes mellitus.

Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
25
Fiscal Year
2002
Total Cost
$228,547
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Hannon, Tamara S; Kirkman, M S; Patel, Yash R et al. (2014) Profound defects in ?-cell function in screen-detected type 2 diabetes are not improved with glucose-lowering treatment in the Early Diabetes Intervention Program (EDIP). Diabetes Metab Res Rev 30:767-76
Patel, Y R; Kirkman, M S; Considine, R V et al. (2013) Effect of acarbose to delay progression of carotid intima-media thickness in early diabetes. Diabetes Metab Res Rev 29:582-91
Kirkman, M Sue; Shankar, R Ravi; Shankar, Sudha et al. (2006) Treating postprandial hyperglycemia does not appear to delay progression of early type 2 diabetes: the Early Diabetes Intervention Program. Diabetes Care 29:2095-101
Wilson, Wayne A; Wang, Zhong; Roach, Peter J (2005) Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p. Biochem Biophys Res Commun 329:161-7
Hermel, Evan; Hart, Andrew J; Gunduz, Irfan et al. (2004) Polymorphism and conservation of the genes encoding Qa1 molecules. Immunogenetics 56:639-49
Pederson, Bartholomew A; Wilson, Wayne A; Roach, Peter J (2004) Glycogen synthase sensitivity to glucose-6-P is important for controlling glycogen accumulation in Saccharomyces cerevisiae. J Biol Chem 279:13764-8
Wilson, Wayne A; Hughes, William E; Tomamichel, Wendy et al. (2004) Increased glycogen storage in yeast results in less branched glycogen. Biochem Biophys Res Commun 320:416-23
Duan, Chaojun; Li, Minghua; Rui, Liangyou (2004) SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol Chem 279:43684-91
Shankar, Sudha S; Mirzamohammadi, Bahram; Walsh, James P et al. (2004) L-carnitine may attenuate free fatty acid-induced endothelial dysfunction. Ann N Y Acad Sci 1033:189-97
Thurmond, Debbie C; Gonelle-Gispert, Carmen; Furukawa, Megumi et al. (2003) Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex. Mol Endocrinol 17:732-42

Showing the most recent 10 out of 151 publications