Abstract

The objective of the Biostatistics Core is to help make quantitative inferences based on research about the causes and control of diabetes and related endocrine and metabolic disorders by consulting and collaborating on relevant research. The Core provides experimental design, data management and data analysis in support of approved projects in the Center. Core personnel also develop novel biostatistical techniques, including models in statistical genetics, that are necessary to improve the analysis of such data. Examples of such biostatistical techniques include; improved estimation of hormone levels in sera from assays, including RIA's; development of a model to identify pulses in hormone secretion from a sequential series of assays; improved methods to include data from dropouts in 'intent to treat' analyses of controlled clinical trials; methods to combine information from multiple endpoints into a single overall test of efficacy; and analysis of pedigree data with emphasis on linkage analysis. Members of this Core will provide expertise in developing additional models in collaboration with investigators from the Michigan Diabetes Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
5P60DK020572-24
Application #
6417654
Study Section
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
24
Fiscal Year
2001
Total Cost
$193,346
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Xiong, Yi; Torsoni, Adriana Souza; Wu, Feihua et al. (2018) Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. Elife 7:
Tank, E M; Figueroa-Romero, C; Hinder, L M et al. (2018) Abnormal RNA stability in amyotrophic lateral sclerosis. Nat Commun 9:2845
Liu, Yan; Jiang, Lin; Sun, Chengxin et al. (2018) Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nat Commun 9:2751
Sheng, Liang; Ye, Lan; Zhang, Dong et al. (2018) New Insights Into the Long Non-coding RNA SRA: Physiological Functions and Mechanisms of Action. Front Med (Lausanne) 5:244
Zhao, Xu-Yun; Xiong, Xuelian; Liu, Tongyu et al. (2018) Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun 9:2986
Dreffs, Alyssa; Henderson, Desmond; Dmitriev, Andrey V et al. (2018) Retinal pH and Acid Regulation During Metabolic Acidosis. Curr Eye Res 43:902-912
Kumar, Navasuja; Pop-Busui, Rodica; Musch, David C et al. (2018) Central Corneal Thickness Increase Due to Stromal Thickening With Diabetic Peripheral Neuropathy Severity. Cornea 37:1138-1142
Wilson, Matthew J; Sen, Ananda; Bridges, Dave et al. (2018) Higher baseline expression of the PTGS2 gene and greater decreases in total colonic fatty acid content predict greater decreases in colonic prostaglandin-E2 concentrations after dietary supplementation with ?-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids 139:14-19
Sucularli, Ceren; Thomas, Peedikayil; Kocak, Hande et al. (2018) High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype. Gene 679:219-231
Kady, Nermin M; Liu, Xuwen; Lydic, Todd A et al. (2018) ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability. Diabetes 67:769-781

Showing the most recent 10 out of 1081 publications