This grant request proposes to expand the operation of a Diabetes Research and Training Center at Washington University School of Medicine. Seven specific objectives of the proposal are: (1) to continue an Administrative Core to coordinate, integrate and provide guidance in the conduct of ongoing diabetes research and to develop and establish new programs in diabetes research (2) to continue to operate five biomedical research cores in Clinical Research and Diabetes Registry, Radioimmunoassay, Pathobiology, Tissue Culture and Mass Spectrometry (3) to organize two new biomedical research cores in molecular biology and human pancreatic islet isolation (4) to continue a Pilot and Feasibility Program (5) to continue a Training and Information Transfer Component (6) to continue a training program for diabetes related research and (7) to continue to provide a liaison with local, regional and national agencies and organizations working in diabetes. The present application seeks a substantial increase in the funding level of this DRTC. This request is based on the expanded use of the established Biomedical Research Cores by a rapidly growing number of established or recently recruited diabetes investigators, as well as the tremendous investments made by the Washington University School of Medicine in expanded physical facilities for the development of new areas of diabetes research. Additional funding is also required to increase the effectiveness of a rapidly developing Training and Information Transfer Component which has succeeded in attracting behavioral scientists and other established researchers new to diabetes research into the DRTC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
5P60DK020579-13
Application #
3108383
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1977-09-01
Project End
1992-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
13
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Zayed, Mohamed A; Hsu, Fong-Fu; Patterson, Bruce W et al. (2018) Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques. J Lipid Res 59:730-738
Xu, Wei; Mukherjee, Sumit; Ning, Yu et al. (2018) Cyclopropane fatty acid synthesis affects cell shape and acid resistance in Leishmania mexicana. Int J Parasitol 48:245-256
Chondronikola, Maria; Magkos, Faidon; Yoshino, Jun et al. (2018) Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Obesity (Silver Spring) 26:683-688
Rajagopal, Rithwick; Zhang, Sheng; Wei, Xiaochao et al. (2018) Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. JCI Insight 3:
van Vliet, Stephan; Smith, Gordon I; Porter, Lane et al. (2018) The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. J Physiol 596:4681-4692
Smith, Gordon I; Commean, Paul K; Reeds, Dominic N et al. (2018) Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study. Obesity (Silver Spring) 26:854-861
Hoekel, James; Narayanan, Anagha; Rutlin, Jerrel et al. (2018) Visual pathway function and structure in Wolfram syndrome: patient age, variation and progression. BMJ Open Ophthalmol 3:e000081
Porter, Lane C; Franczyk, Michael P; Pietka, Terri et al. (2018) NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism. Am J Physiol Endocrinol Metab 315:E520-E530
Howard, Nicole C; Marin, Nancy D; Ahmed, Mushtaq et al. (2018) Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol 3:1099-1108
Mukherjee, Sumit; Xu, Wei; Hsu, Fong-Fu et al. (2018) Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania major. Mol Microbiol :

Showing the most recent 10 out of 978 publications