Abstract

This application requests continued support for the operation of a Core Facility in Mass Spectrometry within the Diabetes Research and Training Center at Washington University. the overall goal of the core is to support diabetes research. The core is an important component of the Mass Spectrometry Resource supported by the Division of Research Resources, Biotechnology Resources Program.
The specific aims of the core are to: 1) Train investigators how to use GC/MS systems and the principles of mass spectrometry. 2) Allow use of GC/MS systems by investigators and their previously trained senior technicians. 3) Provide consultation regarding methodology, data interpretation and problem solving. 4) Provide limited services (quantitative, spectral analysis) for low volume users. 5) Support collaborative research by NIH funded diabetes investigators and leading investigators worldwide. 6) Continue to develop new GC/MS technologies to support diabetes research at Washington University and worldwide.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
2P60DK020579-21
Application #
6270487
Study Section
Project Start
1998-06-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
21
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Howard, Nicole C; Marin, Nancy D; Ahmed, Mushtaq et al. (2018) Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol 3:1099-1108
Mukherjee, Sumit; Xu, Wei; Hsu, Fong-Fu et al. (2018) Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania major. Mol Microbiol :
Musselman, Laura Palanker; Fink, Jill L; Maier, Ezekiel J et al. (2018) Seven-Up Is a Novel Regulator of Insulin Signaling. Genetics 208:1643-1656
Henson, William R; Hsu, Fong-Fu; Dantas, Gautam et al. (2018) Lipid metabolism of phenol-tolerant Rhodococcus opacus strains for lignin bioconversion. Biotechnol Biofuels 11:339
Zayed, Mohamed A; Hsu, Fong-Fu; Patterson, Bruce W et al. (2018) Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques. J Lipid Res 59:730-738
Xu, Wei; Mukherjee, Sumit; Ning, Yu et al. (2018) Cyclopropane fatty acid synthesis affects cell shape and acid resistance in Leishmania mexicana. Int J Parasitol 48:245-256
Chondronikola, Maria; Magkos, Faidon; Yoshino, Jun et al. (2018) Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Obesity (Silver Spring) 26:683-688
Rajagopal, Rithwick; Zhang, Sheng; Wei, Xiaochao et al. (2018) Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. JCI Insight 3:
van Vliet, Stephan; Smith, Gordon I; Porter, Lane et al. (2018) The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. J Physiol 596:4681-4692
Smith, Gordon I; Commean, Paul K; Reeds, Dominic N et al. (2018) Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study. Obesity (Silver Spring) 26:854-861

Showing the most recent 10 out of 978 publications