Abstract

The Amino Acid Assay Subcore provides investigators access to a number of analytical methods related to the measurement of labelled and unlabelled amino acids. The subcore provides space, equipment and personnel for sample analysis and method development. Investigators pay a charge to cover the cost of supplies and pro-rated service contracts. The analyses available include 1) complete amino acid profiles, 2) select amino acid profiles (branched chain or gluconeogenic), 3) amino acid specific activity determinations (alanine, leucine, phenylalanine) and 4) amino acid enrichment (leucine, alpha ketoisocaproate, phenylalanine). With the exception of the rapid assay for leucine and phenylalanine, the user group identified as being associated with this subcore project an increased need for all services offered.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
2P60DK020593-18
Application #
5210422
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Dutter, Brendan F; Ender, Anna; Sulikowski, Gary A et al. (2018) Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org Biomol Chem 16:5575-5579
Herrick, Mary K; Favela, Kristin M; Simerly, Richard B et al. (2018) Attenuation of diet-induced hypothalamic inflammation following bariatric surgery in female mice. Mol Med 24:56
Perez, Katia M; Curley, Kathleen L; Slaughter, James C et al. (2018) Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism. J Clin Endocrinol Metab 103:4265-4274
Marre, Meghan L; McGinty, John W; Chow, I-Ting et al. (2018) Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes. Diabetes 67:1356-1368
Creecy, Amy; Uppuganti, Sasidhar; Unal, Mustafa et al. (2018) Low bone toughness in the TallyHO model of juvenile type 2 diabetes does not worsen with age. Bone 110:204-214
Russart, Kathryn L G; Huk, Danielle; Nelson, Randy J et al. (2018) Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion. Horm Behav 98:121-129
Coppola, Jennifer J; Disney, Anita A (2018) Most calbindin-immunoreactive neurons, but few calretinin-immunoreactive neurons, express the m1 acetylcholine receptor in the middle temporal visual area of the macaque monkey. Brain Behav 8:e01071
Zhu, Lin; Luu, Thao; Emfinger, Christopher H et al. (2018) CETP Inhibition Improves HDL Function but Leads to Fatty Liver and Insulin Resistance in CETP-Expressing Transgenic Mice on a High-Fat Diet. Diabetes 67:2494-2506
Lu, Sichang; McGough, Madison A P; Shiels, Stefanie M et al. (2018) Settable polymer/ceramic composite bone grafts stabilize weight-bearing tibial plateau slot defects and integrate with host bone in an ovine model. Biomaterials 179:29-45
Horwitz, Elad; Krogvold, Lars; Zhitomirsky, Sophia et al. (2018) ?-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes. Diabetes 67:2305-2318

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