The Metabolic Physiology Shared Resource (MPSR) is developed as an institutional core that will allowDRTC investigators to study metabolism using a range of animal models and human subjects. MPSRcomponents include laboratories for study of mice, rats, canines, and human subjects. This resource isshared with two other centers. They are the Mouse Metabolic Phenotyping Center (MMPC) and GeneralClinical Research Center (GCRC). The MMPC provides comprehensive services for study of mice. TheGCRC provides support for human studies in such areas as nutritional services, nursing, physical resources,biostatistics, and bioinformatics. The MMPC and GCRC both have NIH support independent of the DRTC.The DRTC will support laboratories for rat and canine experimentation and for the study of energy balanceand nutrition in human subjects. The Rat Laboratory is an expansion of the DRTC efforts to centralize anddevelop techniques for studying in vivo metabolism (e.g. energy balance, insulin sensitivity, insulin secretion)in the conscious, unrestrained rat. While distinct from the MMPC, this component greatly benefits from andsynergizes with the MMPC. The Canine Laboratory is a continuation of DRTC support of our novel approachto study in vivo metabolism (e.g. liver substrate balance, hormone action) using the conscious dog. TheHuman Energy Balance Laboratory is an essential complement of existing services available to DRTCinvestigators by way of the GCRC. It will support services for assessment of energy expenditure, bodycomposition, and physical activity. The MPSR is directed by faculty (D. Wasserman, S. Davis) experiencedin the range of experimental models supported by the resource and provides specialized technicalassistance to investigators using the resource. The MPSR is structured to facilitate translational studies fromgenetically modified mice to humans and to allow investigators working in human subjects to explore morebasic mechanisms in animal models. The MPSR represents the most efficient and scientifically soundapproach to utilizing institutional resources that have common goals (i.e. study of metabolism in the wholeorganism). The MPSR effectively pools expertise and in some cases physical resources, allowing DRTCinvestigators the ability to study metabolism in scope that is unprecedented.
| Cooke, Allison L; Morris, Jamie; Melchior, John T et al. (2018) A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. J Lipid Res 59:1244-1255 |
| Moore, Mary Courtney; Kelley, David E; Camacho, Raul C et al. (2018) Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts. Diabetes 67:1173-1181 |
| Funkhouser-Jones, Lisa J; van Opstal, Edward J; Sharma, Ananya et al. (2018) The Maternal Effect Gene Wds Controls Wolbachia Titer in Nasonia. Curr Biol 28:1692-1702.e6 |
| Hart, Nathaniel J; Aramandla, Radhika; Poffenberger, Gregory et al. (2018) Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight 3: |
| Warren Andersen, Shaneda; Blot, William J; Shu, Xiao-Ou et al. (2018) Associations Between Neighborhood Environment, Health Behaviors, and Mortality. Am J Prev Med 54:87-95 |
| Sui, Lina; Danzl, Nichole; Campbell, Sean R et al. (2018) ?-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells. Diabetes 67:26-35 |
| Dutter, Brendan F; Ender, Anna; Sulikowski, Gary A et al. (2018) Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org Biomol Chem 16:5575-5579 |
| Herrick, Mary K; Favela, Kristin M; Simerly, Richard B et al. (2018) Attenuation of diet-induced hypothalamic inflammation following bariatric surgery in female mice. Mol Med 24:56 |
| Perez, Katia M; Curley, Kathleen L; Slaughter, James C et al. (2018) Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism. J Clin Endocrinol Metab 103:4265-4274 |
| Marre, Meghan L; McGinty, John W; Chow, I-Ting et al. (2018) Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes. Diabetes 67:1356-1368 |
Showing the most recent 10 out of 1487 publications
