The Ligand Assay Core has been a component of the University of Chicago DRTC since it was first funded in 1977. At the last competitive renewal, the Core was judged to be of outstanding merit. The overall objective of this Core is to help independently funded investigators carrying out research in diabetes and other metabolic disorders by assaying insulin, C-peptide, proinsulin and other hormones. The specific objectives of this Core are: a. to advise and aid independently funded investigators in assaying insulin and other hormones relevant to the study of diabetes and related disorders; b. to develop and implement new assays that may be required by users of the Core Laboratory and modify existing assays to improve throughput and reduce cost; c. to train investigators, fellows, students and other laboratory personnel in the procedures of the Core. Specific services to be offered by this Core are: a. Assays of hormones involved in the control of carbohydrate metabolism including insulin (human and rodent), C-peptide, proinsulin, insulin antibodies, glucagon, pancreatic polypeptide, growth hormone, leptin, cortisol, and free fatty acids; b. Advice and aid to independently funded investigators in methods of assaying insulin and other hormones; c. Development and implementation of new assays that may be required by users of the Core Laboratory and modification of existing assays to improve throughput and reduce cost; d. Training of investigators, fellows, students and other laboratory personnel in the procedures of the Core Laboratory. Dr. Samuel Refetoff will serve as Director and Dr. David Ehrmann will serve as Co-Director.
| Temple, Karla A; Leproult, Rachel; Morselli, Lisa et al. (2018) Sex Differences in the Impact of Obstructive Sleep Apnea on Glucose Metabolism. Front Endocrinol (Lausanne) 9:376 |
| Kirkley, Andrew G; Carmean, Christopher M; Ruiz, Daniel et al. (2018) Arsenic exposure induces glucose intolerance and alters global energy metabolism. Am J Physiol Regul Integr Comp Physiol 314:R294-R303 |
| Morselli, Lisa L; Temple, Karla A; Leproult, Rachel et al. (2018) Determinants of Slow-Wave Activity in Overweight and Obese Adults: Roles of Sex, Obstructive Sleep Apnea and Testosterone Levels. Front Endocrinol (Lausanne) 9:377 |
| Fowler, Jonas L; Lee, Steve Seung-Young; Wesner, Zachary C et al. (2018) Three-Dimensional Analysis of the Human Pancreas. Endocrinology 159:1393-1400 |
| Boland, Brandon B; Brown Jr, Charles; Alarcon, Cristina et al. (2018) ?-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats. Endocrinology 159:895-906 |
| Guyon, Aurore; Morselli, Lisa L; Balbo, Marcella L et al. (2017) Effects of Insufficient Sleep on Pituitary-Adrenocortical Response to CRH Stimulation in Healthy Men. Sleep 40: |
| Yue, Jiping; Gou, Xuewen; Li, Yuanyuan et al. (2017) Engineered Epidermal Progenitor Cells Can Correct Diet-Induced Obesity and Diabetes. Cell Stem Cell 21:256-263.e4 |
| Peek, Clara Bien; Levine, Daniel C; Cedernaes, Jonathan et al. (2017) Circadian Clock Interaction with HIF1? Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle. Cell Metab 25:86-92 |
| Graff, Mariaelisa; Emery, Leslie S; Justice, Anne E et al. (2017) Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos. Lipids Health Dis 16:200 |
| Penckofer, Sue; Byrn, Mary; Adams, William et al. (2017) Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes. J Diabetes Res 2017:8232863 |
Showing the most recent 10 out of 848 publications
