Abstract

1.
AIMS 1. To identify individuals at risk for having the hemoglobin S gene, for hemoglobin phenotype testing and counseling. 2. To provide education and non-directive counseling to individuals at risk for having children with sickle cell disease. 3. To make education and counseling easily accessible to individuals within the health facilities in their own community. 4. To increase the general public's awareness of sickle cell trait, sickle cell disease and other hemoglobinopathies. 5. To increase the availability of information to the general public and health professionals about sickle cell disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL015157-31
Application #
6630617
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
31
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Steinberg, Martin H; Sebastiani, Paola (2012) Genetic modifiers of sickle cell disease. Am J Hematol 87:795-803
Loscalzo, Joseph (2012) Irreproducible experimental results: causes, (mis)interpretations, and consequences. Circulation 125:1211-4
Vandorpe, David H; Xu, Chang; Shmukler, Boris E et al. (2010) Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One 5:e8732
Jahangir, Eiman; Vita, Joseph A; Handy, Diane et al. (2009) The effect of L-arginine and creatine on vascular function and homocysteine metabolism. Vasc Med 14:239-48
Casula, Sabina; Zolotarev, Alexander S; Stuart-Tilley, Alan K et al. (2009) Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporter. Blood Cells Mol Dis 42:233-40
Steinberg, Martin H; Voskaridou, Ersi; Kutlar, Abdullah et al. (2003) Concordant fetal hemoglobin response to hydroxyurea in siblings with sickle cell disease. Am J Hematol 72:121-6
Ware, Russell E; Eggleston, Barry; Redding-Lallinger, Rupa et al. (2002) Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy. Blood 99:10-4
Mirchev, R; Golan, D E (2001) Single-particle tracking and laser optical tweezers studies of the dynamics of individual protein molecules in membranes of intact human and mouse red cells. Blood Cells Mol Dis 27:143-7
Jiang, L; Jha, V; Dhanabal, M et al. (2001) Intracellular Ca(2+) signaling in endothelial cells by the angiogenesis inhibitors endostatin and angiostatin. Am J Physiol Cell Physiol 280:C1140-50
Shmukler, B E; Brugnara, C; Alper, S L (2000) Structure and genetic polymorphism of the mouse KCC1 gene. Biochim Biophys Acta 1492:353-61

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