Abstract

The Cincinnati Comprehensive Sickle Cell Center proposes to continue and expand a high quality program which encompasses the components of research, patient surveillance, education, testing and counseling. The basic and clinical research projects which are all interrelated include investigations of infection and its prevention, the switch mechanism of fetal Hgb, viscosity, and the microcirculation, cardiorespiratory changes in sickle cell disease and the use of hypertransfusion. This combination of the basic and clinical research program, and the clinical evaluation and application related to patient surveillance and the evaluation of education training, testing and counseling; will promote correlation of results from research and feasibility for service. The Sickle Cell Center will also enable a concentration of resources and manpower to provide a program with many varied components in a coordinated fashion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL015996-15
Application #
3108449
Study Section
(SRC)
Project Start
1978-04-01
Project End
1988-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
15
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229

  Publications

Graumlich, S E; Powers, S W; Byars, K C et al. (2001) Multidimensional assessment of pain in pediatric sickle cell disease. J Pediatr Psychol 26:203-14
Bellet, P S; Kalinyak, K A; Shukla, R et al. (1995) Incentive spirometry to prevent acute pulmonary complications in sickle cell diseases. N Engl J Med 333:699-703
Cotter, P D; Rucknagel, D L; Bishop, D F (1994) X-linked sideroblastic anemia: identification of the mutation in the erythroid-specific delta-aminolevulinate synthase gene (ALAS2) in the original family described by Cooley. Blood 84:3915-24
Johnson, K; Stastny, J F; Rucknagel, D L (1994) Fat embolism syndrome associated with asthma and sickle cell-beta(+)-thalassemia. Am J Hematol 46:354-7
Morris, C L; Rucknagel, D L; Joiner, C H (1993) Deoxygenation-induced changes in sickle cell-sickle cell adhesion. Blood 81:3138-45
Morris, C L; Gruppo, R A; Shukla, R et al. (1991) Influence of plasma and red cell factors on the rheologic properties of oxygenated sickle blood during clinical steady state. J Lab Clin Med 118:332-42
McConnell, M E; Daniels, S R; Lobel, J et al. (1989) Hemodynamic response to exercise in patients with sickle cell anemia. Pediatr Cardiol 10:141-4
Morris, C L; Rucknagel, D L; Shukla, R et al. (1989) Evaluation of the yield stress of normal blood as a function of fibrinogen concentration and hematocrit. Microvasc Res 37:323-38
Cyran, S E; James, F W; Daniels, S et al. (1988) Comparison of the cardiac output and stroke volume response to upright exercise in children with valvular and subvalvular aortic stenosis. J Am Coll Cardiol 11:651-8