Abstract

This unit will provide administration, data management and statistical analysis to all activities of the Center. The Center Director and his administration will have the financial responsibility for the conduct of this project. The data management unit will store into our computer all the data from the clinical units and research units. It will provide clinical summaries and tabular computation of laboratory data for all patients to be used in the clinical setting and it will provide information to all studies of the Center. The data management unit will therefore unify and coordinate all activities of the Center. The Center statisticians will assist all investigators of the Center. A special project of this unit will be the statistical analysis of all the genetic and hematological data to assess their correlation with clinical symptomatology. This study aims at the development of prognostic factors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL028381-14
Application #
5213377
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Prohovnik, Isak; Hurlet-Jensen, Anne; Adams, Robert et al. (2009) Hemodynamic etiology of elevated flow velocity and stroke in sickle-cell disease. J Cereb Blood Flow Metab 29:803-10
Manwani, Deepa; Galdass, Mariann; Bieker, James J (2007) Altered regulation of beta-like globin genes by a redesigned erythroid transcription factor. Exp Hematol 35:39-47
Weinberg, Rona S; Ji, Xinjun; Sutton, Millicent et al. (2005) Butyrate increases the efficiency of translation of gamma-globin mRNA. Blood 105:1807-9
Rubin, Camelia Iancu; French, Deborah L; Atweh, George F (2003) Stathmin expression and megakaryocyte differentiation: a potential role in polyploidy. Exp Hematol 31:389-97
Day, Nancy S; Tadin, Marija; Christiano, Angela M et al. (2002) Rapid prenatal diagnosis of sickle cell diseases using oligonucleotide ligation assay coupled with laser-induced capillary fluorescence detection. Prenat Diagn 22:686-91
Turhan, Aslihan; Weiss, Linnea A; Mohandas, Narla et al. (2002) Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci U S A 99:3047-51
Iancu, C; Mistry, S J; Arkin, S et al. (2001) Effects of stathmin inhibition on the mitotic spindle. J Cell Sci 114:909-16
Frenette, P S; Weiss, L (2000) Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms. Blood 96:2460-8
Pearson, M J; Lipowsky, H H (2000) Influence of erythrocyte aggregation on leukocyte margination in postcapillary venules of rat mesentery. Am J Physiol Heart Circ Physiol 279:H1460-71
O'Neill, D W; Schoetz, S S; Lopez, R A et al. (2000) An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol Cell Biol 20:7572-82

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