The Comprehensive Sickle Cell Center of Manhattan is a consortium of 2 medical schools (Columbia and Mt. Sinai) and 4 hospitals (Presbyterian, St. Luke's-Roosevelt, Harlem and Mt. Sinai). The population of patients served consists of 900 individuals, nearly all the patients in the island of Manhattan with sickle cell diseases. The clinical units of the Center provide """"""""state-of-the art"""""""" personalized clinical care to the patients, who, in turn, participate in a variety of research projects. One main goal of research activities of the Center focuses on the molecular biology approach to the disease The gene transfer goal is pursued in animals and in vitro, with the control of hemoglobin switching and the creation of transgenic mice as an animal model of the disease as parallel approaches. The patients are genetically classified in detail by DNA analysis and their genotype correlated with clinical manifestation and hematological data to derive prognostic factors that could be used to target therapy. Another area of the Center focuses on therapy: the use of intermittent butyrate therapy offers the promise of increasing Hgb F (it has been shown by another unit of the Center that a HgbF percentage as low as >4% is protective against stroke). Another therapeutic approach is the trial of oral Fe chelator for the patients on chronic transfusion. Studies of neuropsychological damage are correlated with humoral studies of coagulation and of molecules reflecting endothelial damage and integrated with """"""""in vivo"""""""" studies of microcirculation. The Center aims to provide cohesion and synergy to all project. The center is assisted by an administrative and statistical core, my a molecular biology and hematological laboratory core, and by an erythropoiesis laboratory core.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
2P60HL028381-16
Application #
2357370
Study Section
Special Emphasis Panel (ZHL1-CSR-Q (S1))
Project Start
1983-04-01
Project End
2003-03-31
Budget Start
1998-04-24
Budget End
1999-03-31
Support Year
16
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Pediatrics
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Prohovnik, Isak; Hurlet-Jensen, Anne; Adams, Robert et al. (2009) Hemodynamic etiology of elevated flow velocity and stroke in sickle-cell disease. J Cereb Blood Flow Metab 29:803-10
Manwani, Deepa; Galdass, Mariann; Bieker, James J (2007) Altered regulation of beta-like globin genes by a redesigned erythroid transcription factor. Exp Hematol 35:39-47
Weinberg, Rona S; Ji, Xinjun; Sutton, Millicent et al. (2005) Butyrate increases the efficiency of translation of gamma-globin mRNA. Blood 105:1807-9
Rubin, Camelia Iancu; French, Deborah L; Atweh, George F (2003) Stathmin expression and megakaryocyte differentiation: a potential role in polyploidy. Exp Hematol 31:389-97
Day, Nancy S; Tadin, Marija; Christiano, Angela M et al. (2002) Rapid prenatal diagnosis of sickle cell diseases using oligonucleotide ligation assay coupled with laser-induced capillary fluorescence detection. Prenat Diagn 22:686-91
Turhan, Aslihan; Weiss, Linnea A; Mohandas, Narla et al. (2002) Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci U S A 99:3047-51
Iancu, C; Mistry, S J; Arkin, S et al. (2001) Effects of stathmin inhibition on the mitotic spindle. J Cell Sci 114:909-16
Lung, H Y; Meeus, I S; Weinberg, R S et al. (2000) In vivo silencing of the human gamma-globin gene in murine erythroid cells following retroviral transduction. Blood Cells Mol Dis 26:613-9
Frenette, P S; Weiss, L (2000) Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms. Blood 96:2460-8
Pearson, M J; Lipowsky, H H (2000) Influence of erythrocyte aggregation on leukocyte margination in postcapillary venules of rat mesentery. Am J Physiol Heart Circ Physiol 279:H1460-71

Showing the most recent 10 out of 114 publications