The ultimate goal of this project is to improve the health care of sickle cell patients. This will be pursued through providing programs which expedite the transfer of knowledge and technology related to sickle cell disease to health care providers at the Center, in the community and the regions that the Center serves. Thus, the research through a research assistantship program, (2) to offer graduate education programs targeted for primary care physicians at the resident level patient and (3) to provide continuing medical education in care for the sickle cell nurse, and counselors practicing in the Mobile area and surrounding countries through local, regional and national meetings organized from the USA Comprehensive Sickle Cell Center. During these education programs, various barriers to health care will be assessed particularly as they pertain to physicians attitudes toward pain management in sickle cell disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL038639-12
Application #
6109865
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
12
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of South Alabama
Department
Type
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688
Pace, B S; Qian, X; Ofori-Acquah, S F (2004) Selective inhibition of beta-globin RNA transcripts by antisense RNA molecules. Cell Mol Biol (Noisy-le-grand) 50:43-51
Haynes Jr, Johnson; Baliga, B Surendra; Obiako, Boniface et al. (2004) Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway. Blood 103:3945-50
Haynes Jr, Johnson; Obiako, Boniface (2002) Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. Am J Physiol Heart Circ Physiol 282:H122-30
Foley, Heather A; Ofori-Acquah, Solomon F; Yoshimura, Akihiko et al. (2002) Stat3 beta inhibits gamma-globin gene expression in erythroid cells. J Biol Chem 277:16211-9
Abraham, Ann; Bencsath, F Aladar; Shartava, Archil et al. (2002) Preparation of irreversibly sickled cell beta-actin from normal red blood cell beta-actin. Biochemistry 41:292-6
Kakhniashvili, D G; Goodman, S R (2001) Isolation of spectrin subunits by reverse-phase high-performance liquid chromatography. Protein Expr Purif 23:249-51
Sangerman, J; Kakhniashvili, D; Brown, A et al. (2001) Spectrin ubiquitination and oxidative stress: potential roles in blood and neurological disorders. Cell Mol Biol Lett 6:607-36
Yang, Y M; Pace, B (2001) Pharmacologic induction of fetal hemoglobin synthesis: cellular and molecular mechanisms. Pediatr Pathol Mol Med 20:87-106
Cepeda, M L; Allen, F H; Cepeda, N J et al. (2000) Physical growth, sexual maturation, body image and sickle cell disease. J Natl Med Assoc 92:4-Oct
Xu, L; Ferry, A E; Monteiro, C et al. (2000) Beta globin gene inhibition by antisense RNA transcripts. Gene Ther 7:438-44

Showing the most recent 10 out of 54 publications