This core will have three functions: 1) Interface the Program with the well established and highly successful, Transgenic and Gene Targeting Facility available at the Albert Einstein College of Medicine. In this facility transgenic mice will be generated with DNA constructs supplied by Core B. This function will be mainly to provide assistance to investigators in the labeling, identification and record keeping of the founders and their future generations. 2) Identify founders expressing the desired hemoglobins or red cell transporters, characterize them and provide assistance with breeding strategies of the founders. These include, breeding them to the transgenic mice expressing alphaH BetaS, the alpha-knockout, the Beta-knockouts, or to other transgenic and knockout lines available. 3) Breed transgenic mice which will be identified and characterized for use in Project 1 (Two animal models of organ damage in sickle cell disease); Project 2 (Transgenic expressing HbC and HbS and HbC simultaneously; Project 6 (Transgenic mice expression human K:C1 co-transport).
| Olivier, Emmanuel N; Rybicki, Anne C; Bouhassira, Eric E (2006) Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells. Stem Cells 24:1914-22 |
| Srinivasulu, Sonati; Perumalsamy, Krishnaveni; Upadhya, Rajendra et al. (2006) Pair-wise interactions of polymerization inhibitory contact site mutations of hemoglobin-S. Protein J 25:503-16 |
| Oh, Il-Hoan; Fabry, Mary E; Humphries, R Keith et al. (2004) Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells. Exp Hematol 32:461-9 |
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| Kaul, Dhananjay K; Fabry, Mary E (2004) In vivo studies of sickle red blood cells. Microcirculation 11:153-65 |
| Romero, Jose R; Suzuka, Sandra M; Nagel, Ronald L et al. (2004) Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells. Blood 103:2384-90 |
| Wang, Jian-Ying; Drlica, Karl (2003) Modeling hybridization kinetics. Math Biosci 183:37-47 |
| Alami, Raouf; Fan, Yuhong; Pack, Stephanie et al. (2003) Mammalian linker-histone subtypes differentially affect gene expression in vivo. Proc Natl Acad Sci U S A 100:5920-5 |
| Dewan, John C; Feeling-Taylor, Angela; Puius, Yoram A et al. (2002) Structure of mutant human carbonmonoxyhemoglobin C (betaE6K) at 2.0 A resolution. Acta Crystallogr D Biol Crystallogr 58:2038-42 |
| Chen, Qiuying; Bonaventura, Celia; Nagel, Ronald L et al. (2002) Distinct domain responses of R-state human hemoglobins A, C, and S to anions. Blood Cells Mol Dis 29:119-32 |
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