PI M. Fabry will use blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) and other non- invasive techniques to study the impact of factors modulating vaso- occlusion on the intact animals with particular emphasis on the liver and kidneys. The investigators will examine the effect of the modulating factors nitric oxide synthase, drugs proposed for treatment of SCD (hydroxyurea, clotrimazole, and its major metabolite) and adhesion The investigators speculate that adhesion may play a major role in the liver lesions characteristic of transgenic mice.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL038655-15
Application #
6593856
Study Section
Project Start
2002-05-20
Project End
2003-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
15
Fiscal Year
2002
Total Cost
$175,153
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
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