Abstract

The purpose of this proposal is to continue the concept of the Comprehensive Sickle Cell Center at Meharry Medical College. The """"""""Center"""""""" currently has components in the area of: o Research (basic, clinical and applied), o Genetic Screening, o Laboratory Services, o Education, o Patient Care (infants, children, adults), o Community Outreach, and o Genetic counseling. In addition to the continuation of the above activities the """"""""Center"""""""" during the next funding period plans to expand its programs and place more emphasis on the newborn who is discovered through the State of Tennessee newborn screening program. The """"""""Center"""""""" has already started to explore the opportunity to develop collaboration with other centers. In addition there is the opportunity to also develop a stronger relationship with industry.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL038737-07
Application #
2219018
Study Section
Special Emphasis Panel (SRC (SH))
Project Start
1988-04-01
Project End
1998-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Meharry Medical College
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37208

  Publications

Burch-Sims, G Pamela; Matlock, Valeria R (2005) Hearing loss and auditory function in sickle cell disease. J Commun Disord 38:321-9
Aguinaga, M D; Kutlar, F; Turner, E A et al. (2000) Hb Inkster [alpha85(F6)Asp-->Val] found in a caucasian male with polycythemia. Hemoglobin 24:333-9
Shokrani, M; Terrell, F; Turner, E A et al. (2000) Chromatographic measurements of hemoglobin A2 in blood samples that contain sickle hemoglobin. Ann Clin Lab Sci 30:191-4
Popp, R A; Shinpock, S G; Qopp, D M et al. (1998) Erythropoietin level and effect of rHuEPO in beta-thalassemic mice. Ann N Y Acad Sci 850:455-8
Iyamu, E W; Roa, P D; Kopsombut, P et al. (1998) New isocratic high-performance liquid chromatographic procedure to assay the anti-sickling compound hydroxyurea in plasma with ultraviolet detection. J Chromatogr B Biomed Sci Appl 709:119-26
Roa, D; Kopsombut, P; Aguinaga, M P et al. (1997) Hydroxyurea-induced denaturation of normal and sickle cell hemoglobins in vitro. J Clin Lab Anal 11:208-13
Roa, D; Turner, E A; Aguinaga, M D (1995) Reference ranges for hemoglobin variants by HPLC in African Americans. Ann Clin Lab Sci 25:228-35
Robbins, V; Aguinaga, M P; Valenzuela, M S (1995) Efficient isolation of whole genomic DNA from cell cultures and blood samples. Biotechniques 18:414-6, 418
Roa, P D; Turner, E A; Aguinaga, M del P (1993) Hemoglobin variant detection from dried blood specimens by high performance liquid chromatography. Ann Clin Lab Sci 23:433-8
Chakrabarti, A; Sitaric, S; Ohi, S (1992) A procedure for large-scale plasmid isolation without using ultracentrifugation. Biotechnol Appl Biochem 16:211-5

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