Abstract

The focus of the Micronutrient-Genomic Interactions Research Core is to achieve that integration by combining basic molecular approaches and clinical investigations. A potential outcome of this research is a better understanding of the role of dietary micronutrients in human disease. Current dietary guidelines focus primarily on macronutrient intake and do not consider genetic diversity among individuals. Yet, it is known that genetics has a strong influence on both an individual's susceptibility to disease and that individual's response to diet components. Studying the interaction between micronutrients and genetics will facilitate individualized dietary interventions that are based on the genetic make-up of individuals or population subgroups. This strategy should maximize the benefit of dietary change on health outcomes and minimize the risk of harm associated with giving the same dietary and/or supplement recommendations to genetically diverse populations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Comprehensive Center (P60)
Project #
5P60MD000222-04
Application #
7525333
Study Section
Special Emphasis Panel (ZMD1)
Project Start
Project End
Budget Start
2006-01-01
Budget End
2006-12-31
Support Year
4
Fiscal Year
2006
Total Cost
$23,198
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Engel, Stephanie M; Bradman, Asa; Wolff, Mary S et al. (2016) Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts. Environ Health Perspect 124:822-30
Harley, Kim G; Engel, Stephanie M; Vedar, Michelle G et al. (2016) Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. Environ Health Perspect 124:1084-92
O'Sullivan, Aifric; Armstrong, Patrice; Schuster, Gertrud U et al. (2014) Habitual diets rich in dark-green vegetables are associated with an increased response to ?-3 fatty acid supplementation in Americans of African ancestry. J Nutr 144:123-31
Dawson, Kevin; Zhao, Ling; Adkins, Yuriko et al. (2012) Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. J Nutr Biochem 23:616-21
Armstrong, Patrice; Kelley, Darshan S; Newman, John W et al. (2012) Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans. J Nutr 142:1417-28
Galvez, Alfredo F; Huang, Liping; Magbanua, Mark M J et al. (2011) Differential expression of thrombospondin (THBS1) in tumorigenic and nontumorigenic prostate epithelial cells in response to a chromatin-binding soy peptide. Nutr Cancer 63:623-36
Stephensen, Charles B; Armstrong, Patrice; Newman, John W et al. (2011) ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. J Lipid Res 52:991-1003
Hartiala, Jaana; Li, Dalin; Conti, David V et al. (2011) Genetic contribution of the leukotriene pathway to coronary artery disease. Hum Genet 129:617-27
Aranda, Núria; Viteri, Fernando E; Montserrat, Carme et al. (2010) Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain. Ann Hematol 89:767-73
Hall, Laura M; Kimlin, Michael G; Aronov, Pavel A et al. (2010) Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations. J Nutr 140:542-50

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