Established in January 2003, the mission of the NCMHD Center of Excellence in Nutritional Genomics, a collaborative program between UCD and Children's Hospital Oakland Research Institute, is to reduce and ultimately eliminate racial and ethnic health disparities resulting from gene x environment interactions, particularly those involving genetic, dietary, economic, and cultural factors. Our goal is to devise genome-based dietary interventions to prevent, delay, and treat diseases such as Type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), prostate cancer and asthma. To achieve this goal, the Center is taking an interdisciplinary approach to develop culturally competent methods and novel technologies to elucidate the complex interactions between environmental triggers, genes, and disease. Using a multiorganizational structure and a translational research approach, the Center will investigate the influence of diet and individual genetic variation as risk factors for health disparities in racial/ethnic populations in the U.S. Although certain genotypes are more severely affected by specific types of dietary factors than other genotypes, no genotype is completely immune to the deleterious effects of poor diet. We are using various genomic/informatic technologies to identify and characterize genes regulated by naturally occurring constituents in foods and those gene-subsets that influence the balance between health and disease. Such knowledge is necessary, but not sufficient, to address health disparities among racial/ethnic populations and the poor. Social, economic and cultural factors also come into play when selecting foods and when designing studies to identify causative genes and environmental factors. The specific objectives of the Center include: (1) Developing better approaches for human association studies that recognize the importance of population stratification in racially/ethnically mixed populations; (2) Integrating and translating genetic, genpmic, clinical and pathological information into medical insights that can be used to improve the quality of patient care; (3) Educating students, health care professionals and biomedical researchers about the biological and non-biological factors contributing to health disparities; (4) Establishing community engagement programs to inform health disparity communities about the importance of good nutrition and its relationship to genetic variation and ancestral background. The focus of this competitive renewal application is on research projects that will generate new knowledge and insights into the biologic factors contributing to health disparities. Our proposal includes nutritional genomic studies that will reduce health disparities by providing clinicians, physicians and public health professionals a better understanding of how environmental factors can influence the complex interactions between phenotype and genotype.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZMD1-TC (03))
Program Officer
Castille, Dorothy M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Anatomy/Cell Biology
Schools of Arts and Sciences
United States
Zip Code
Engel, Stephanie M; Bradman, Asa; Wolff, Mary S et al. (2016) Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts. Environ Health Perspect 124:822-30
Harley, Kim G; Engel, Stephanie M; Vedar, Michelle G et al. (2016) Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. Environ Health Perspect 124:1084-92
O'Sullivan, Aifric; Armstrong, Patrice; Schuster, Gertrud U et al. (2014) Habitual diets rich in dark-green vegetables are associated with an increased response to ?-3 fatty acid supplementation in Americans of African ancestry. J Nutr 144:123-31
Dawson, Kevin; Zhao, Ling; Adkins, Yuriko et al. (2012) Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. J Nutr Biochem 23:616-21
Armstrong, Patrice; Kelley, Darshan S; Newman, John W et al. (2012) Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans. J Nutr 142:1417-28
Galvez, Alfredo F; Huang, Liping; Magbanua, Mark M J et al. (2011) Differential expression of thrombospondin (THBS1) in tumorigenic and nontumorigenic prostate epithelial cells in response to a chromatin-binding soy peptide. Nutr Cancer 63:623-36
Stephensen, Charles B; Armstrong, Patrice; Newman, John W et al. (2011) ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. J Lipid Res 52:991-1003
Hartiala, Jaana; Li, Dalin; Conti, David V et al. (2011) Genetic contribution of the leukotriene pathway to coronary artery disease. Hum Genet 129:617-27
Aranda, NĂºria; Viteri, Fernando E; Montserrat, Carme et al. (2010) Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain. Ann Hematol 89:767-73
Hall, Laura M; Kimlin, Michael G; Aronov, Pavel A et al. (2010) Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations. J Nutr 140:542-50

Showing the most recent 10 out of 57 publications