Minorities, women, and disadvantaged persons are more likely to have diabetes and suffer the consequences of type 2 diabetes. Recent trials (including ACCORD) have attempted to reduce CVD by intensive management of glucose, lipids, and hypertension in adults with diabetes, with disappointing results, suggesting that normalization of glucose and BP may be associated with increased risks (including mortality, and side effects) without substantial reduction in CVD incidence. A major trial is ongoing (Look AHEAD) testing a different approach;namely to promote lifestyle changes to reduce weight and increase physical activity in order to address the underlying obesity which is exceedingly prevalent among adults with Type 2 DM. One year and 4 year results have been published and demonstrated the feasibility of lifestyle changes in modifying weight and risk factors, with fewer medications rather than more. Because minority and lower SES T2DM patients are highly likely to be overweight or obese, this project aims to translate the Look AHEAD intervention into an intervention suitable for delivery to these populations either in the clinic or the community.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Comprehensive Center (P60)
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Special Emphasis Panel (ZMD1-RN)
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Wake Forest University Health Sciences
United States
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Claudel, Sophie E; Bertoni, Alain G (2018) Exploring the Use of Personal Technology in Type 2 Diabetes Management Among Ethnic Minority Patients: Cross-Sectional Analysis of Survey Data from the Lifestyle Intervention for the Treatment of Diabetes Study (LIFT Diabetes). JMIR Diabetes 3:e5
Savoca, Margaret R; Ludwig, David A; Jones, Stedman T et al. (2017) Geographic Information Systems to Assess External Validity in Randomized Trials. Am J Prev Med 53:252-259
Katula, Jeffrey A; Kirk, Julienne K; Pedley, Carolyn F et al. (2017) The Lifestyle Intervention for the Treatment of Diabetes study (LIFT Diabetes): Design and baseline characteristics for a randomized translational trial to improve control of cardiovascular disease risk factors. Contemp Clin Trials 53:89-99
Giannini, Courtney M; Irby, Megan B; Skelton, Joseph A et al. (2017) Feasibility of a Friendship Network-Based Pediatric Obesity Intervention. Child Obes 13:18-24
Effoe, Valery S; Katula, Jeffrey A; Kirk, Julienne K et al. (2016) The use of electronic medical records for recruitment in clinical trials: findings from the Lifestyle Intervention for Treatment of Diabetes trial. Trials 17:496
Lane, Montez; Bell, Ronny; Latham-Sadler, Brenda et al. (2016) Translational Research Training at Various Levels of Professional Experience to Address Health Disparities. J Best Pract Health Prof Divers 9:1178-1187
Beech, Bettina M; Calles-Escandon, Jorge; Hairston, Kristen G et al. (2013) Mentoring programs for underrepresented minority faculty in academic medical centers: a systematic review of the literature. Acad Med 88:541-9