This longitudinal prospective study was designed to evaluate the long-term effects of maternal alcohol use during pregnancy on offspring health and development. One thousand five hundred twenty-nine women were interviewed during their 5th month of pregnancy regarding beverage and drug ingestion and a follow-up cohort of approximately 500 infants was examined on days 1 and 2, at eight and eighteen months and at 4 years and 7 years of age. The child's assessments have had two emphases: (1) laboratory and clinical tests of behavioral and neuropsychologic parameters reflecting central nervous system dysfuncton; and (2) anthropometric and dysmorphologic examinations reflecting deviations in growth and morphogenesis. Whenever possible, multiple regression analyses are used to statistically adjust for a wide variety of potentially confounding and intervening variables that can also affect development. Thirty-eight papers are available from the project including empirical outcome papers, methodologic papers, review papers, and clinical papers. The present 3-year renewal is for data analysis, interpretation, and write-up of existing data which has just been gathered at the 7 year evaluation, and integration of data from all prior evaluations of this cohort.
| Connor, Paul D; Sampson, Paul D; Streissguth, Ann P et al. (2006) Effects of prenatal alcohol exposure on fine motor coordination and balance: A study of two adult samples. Neuropsychologia 44:744-51 |
| Kelly, S J; Day, N; Streissguth, A P (2000) Effects of prenatal alcohol exposure on social behavior in humans and other species. Neurotoxicol Teratol 22:143-9 |
| Streissguth, A P; O'Malley, K (2000) Neuropsychiatric implications and long-term consequences of fetal alcohol spectrum disorders. Semin Clin Neuropsychiatry 5:177-90 |
| Connor, P D; Sampson, P D; Bookstein, F L et al. (2000) Direct and indirect effects of prenatal alcohol damage on executive function. Dev Neuropsychol 18:331-54 |
| Connor, P D; Streissguth, A P; Sampson, P D et al. (1999) Individual differences in auditory and visual attention among fetal alcohol-affected adults. Alcohol Clin Exp Res 23:1395-402 |
| Streissguth, A P; Bookstein, F L; Barr, H M et al. (1998) A fetal alcohol behavior scale. Alcohol Clin Exp Res 22:325-33 |
| Baer, J S; Barr, H M; Bookstein, F L et al. (1998) Prenatal alcohol exposure and family history of alcoholism in the etiology of adolescent alcohol problems. J Stud Alcohol 59:533-43 |
| Olson, H C; Feldman, J J; Streissguth, A P et al. (1998) Neuropsychological deficits in adolescents with fetal alcohol syndrome: clinical findings. Alcohol Clin Exp Res 22:1998-2012 |
| Olson, H C; Streissguth, A P; Sampson, P D et al. (1997) Association of prenatal alcohol exposure with behavioral and learning problems in early adolescence. J Am Acad Child Adolesc Psychiatry 36:1187-94 |
| Kerns, K A; Don, A; Mateer, C A et al. (1997) Cognitive deficits in nonretarded adults with fetal alcohol syndrome. J Learn Disabil 30:685-93 |
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