Recent neuropsychological studies have detected a variety of behavioral deficits in abstinent alcoholics. It has been noted that the cognitive deficits observed in alcoholics are quite similar to those manifested in healthy old individuals. These results have prompted numerous investigators to conclude that prolonged alcohol abuse produces a premature or accelerated aging of the brain. Because of the tenuous relationship between brain loci and behavioral functions it is not possible to infer pathophysiological processes from behavioral deficits. The objectives of the proposed project are to develop a comprehensive neurophysiological profile of CNS dysfunction, unique to abstinent alcoholics. The nature of CNS deficits in alcoholics will be ascertained by employing an evoked brain potential diagnostic battery designed to tap various brain functions. This neurodiagnostic battery will be given to abstinent chronic alcoholics, and control subjects between the ages of 21 and 71. We will investigate the """"""""accelerated aging"""""""" hypothesis of alcoholism. Furthermore we will assess whether the aging brain is more sensitive to the deleterious effects of alcohol than the younger brain. Finally we plan to study the possible heterogeneity of neurophysiological deficits in chronic alcoholics in order to identify clusters of CNS dysfunctions. An attempt will be made to relate these brain deficits to various clinical variables.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA002686-09
Application #
3108796
Study Section
Alcohol Biomedical Research Review Committee (ALCB)
Project Start
1979-08-01
Project End
1988-02-29
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Suny Downstate Medical Center
Department
Type
Schools of Medicine
DUNS #
068552207
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
Pandey, Ashwini Kumar; Ardekani, Babak Assai; Kamarajan, Chella et al. (2018) Lower Prefrontal and Hippocampal Volume and Diffusion Tensor Imaging Differences Reflect Structural and Functional Abnormalities in Abstinent Individuals with Alcohol Use Disorder. Alcohol Clin Exp Res 42:1883-1896
Pandey, Ashwini K; Kamarajan, Chella; Manz, Niklas et al. (2016) Delta, theta, and alpha event-related oscillations in alcoholics during Go/NoGo task: Neurocognitive deficits in execution, inhibition, and attention processing. Prog Neuropsychopharmacol Biol Psychiatry 65:158-71
Kamarajan, Chella; Pandey, Ashwini K; Chorlian, David B et al. (2015) The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies. Int J Psychophysiol 97:310-22
Kamarajan, Chella; Porjesz, Bernice (2015) Advances in Electrophysiological Research. Alcohol Res 37:53-87
Rangaswamy, Madhavi; Porjesz, Bernice (2014) Understanding alcohol use disorders with neuroelectrophysiology. Handb Clin Neurol 125:383-414
Pandey, A K; Kamarajan, C; Tang, Y et al. (2012) Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. Biol Psychol 89:170-82
Pandey, Ashwini K; Kamarajan, Chella; Rangaswamy, Madhavi et al. (2012) Event-Related Oscillations in Alcoholism Research: A Review. J Addict Res Ther Suppl 7:
Kamarajan, Chella; Rangaswamy, Madhavi; Manz, Niklas et al. (2012) Topography, power, and current source density of ? oscillations during reward processing as markers for alcohol dependence. Hum Brain Mapp 33:1019-39
Kamarajan, Chella; Rangaswamy, Madhavi; Tang, Yongqiang et al. (2010) Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. J Psychiatr Res 44:576-90
Roopesh, Bangalore N; Rangaswamy, Madhavi; Kamarajan, Chella et al. (2010) Reduced resource optimization in male alcoholics: N400 in a lexical decision paradigm. Alcohol Clin Exp Res 34:1905-14

Showing the most recent 10 out of 62 publications