The broad objective of this research program has been to develop an empirically based understanding of alcoholics and their families, and in so doing, to contribute to the methodological, descriptive, and predictive goals of the field. To this end, the project's past 19 years have involved in-depth assessments of 287 families, including individual, marital, parental, and whole family measures. Initial assessments include psychiatric and family history assessments, videotaped laboratory interactions under drinking and nondrinking conditions, audiotaped home interactions, a variety of interview and questionnaire self reports, and neurological and academic assessments of children. Five and ten year follow-up assessments have been completed on the first samples (50 families of male alcoholics, 50 families of male depressives, 50 families of non-distressed social drinkers), and a five year follow-up has been completed on the second samples (37 families of female alcoholics, 50 families of female depressives, and another 50 families of male alcoholics). The proposed four-year renewal involves completion of a parallel ten year follow-up assessment of the psychiatric/personality, drinking, and psychosocial status of the second samples, as well as further assessment of offspring in the first samples who have now attained adult life roles. Comprehensive interview and questionnaire procedures will be gathered from parents, offspring, and spouses of married adult children, with a projected data base over 1600 individuals.
Specific aims i nclude examination of: 1) predictor domains that moderate and/or mediate the nature and severity of adult child outcomes; 2) effects related to gender of affected parent, gender of offspring, and subtype of alcoholism exhibited by the affected parent; 3) intergenerational relationships of adult offspring and family of origin, and the impact of these relationships on drinking and nondrinking outcomes; 4) risk factors and developmental pathways specific to depressive disorders; and 5) further, complex sequential analyses of naturalistic observational data given the recent completion of detailed coding of all observational data in the second samples.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Project (R01)
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Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Chiapella, Page
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University of Pittsburgh
Schools of Medicine
United States
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Jacob, T; Leonard, K E; Randolph Haber, J (2001) Family interactions of alcoholics as related to alcoholism type and drinking condition. Alcohol Clin Exp Res 25:835-43
Jacob, T; Johnson, S L (2001) Sequential interactions in the parent-child communications of depressed fathers and depressed mothers. J Fam Psychol 15:38-52
Jacob, T; Haber, J R; Leonard, K E et al. (2000) Home interactions of high and low antisocial male alcoholics and their families. J Stud Alcohol 61:72-80
Jacob, T; Windle, M (2000) Young adult children of alcoholic, depressed and nondistressed parents. J Stud Alcohol 61:836-44
Johnson, S L; Jacob, T (2000) Sequential interactions in the marital communication of depressed men and women. J Consult Clin Psychol 68:12-Apr
Seilhamer, R A; Jacob, T; Dunn, N J (1993) The impact of alcohol consumption on parent-child relationships in families of alcoholics. J Stud Alcohol 54:189-98
Tarter, R E; Kabene, M; Escallier, E A et al. (1990) Temperament deviation and risk for alcoholism. Alcohol Clin Exp Res 14:380-2
Jacob, T; Seilhamer, R A; Rushe, R H (1989) Alcoholism and family interaction: an experimental paradigm. Am J Drug Alcohol Abuse 15:73-91
Tarter, R E; Jacob, T; Bremer, D L (1989) Specific cognitive impairment in sons of early onset alcoholics. Alcohol Clin Exp Res 13:786-9
Tarter, R E; Jacob, T; Bremer, D A (1989) Cognitive status of sons of alcoholic men. Alcohol Clin Exp Res 13:232-5

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