Abstract

Six groups of subjects consisting of: 1) alcoholics without liver disease; 2) alcoholics with fatty liver (steatosis) or fibrosis; 3) alcoholics with cirrhosis with or without hepatitis; 4) nonalcoholic cirrhotics; 5) Cronh's Disease, and 6) normals will be examined to assess for the role and impact of hepatic pathology on neurologic impairment. A seventh group of subjects will also be examined prior to and again one year after, liver transplantation. The objectives of this investigation are to determine a) the association between type and severity of liver pathology on CNS functioning in alcoholics; b) the extent to which liver transplantation can reverse the manifest impairments; and, c) the extent to which hepatic function measures can account for the variance on various indices of dysfunction. This information has substantial ramifications for improving the diagnosis and medical management of alcoholism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA006601-02
Application #
3109788
Study Section
(SRC)
Project Start
1985-02-01
Project End
1988-01-31
Budget Start
1986-02-01
Budget End
1987-01-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Tarter, R E (1998) Quality of life following liver transplantation. Hepatogastroenterology 45:1398-403
Panzak, G; Tarter, R; Murali, S et al. (1998) Isometric muscle strength in alcoholic and nonalcoholic liver-transplantation candidates. Am J Drug Alcohol Abuse 24:499-512
Tarter, R E; Panzak, G; Switala, J et al. (1997) Isokinetic muscle strength and its association with neuropsychological capacity in cirrhotic alcoholics. Alcohol Clin Exp Res 21:191-6
Tarter, R E; Switala, J; Lu, S et al. (1995) Abstracting capacity in cirrhotic alcoholics: negative findings. J Stud Alcohol 56:99-103
Salem, O; Dindzans, V J; Freeman, J et al. (1994) Liver transplantation following preoperative closure of intrapulmonary shunts. J Okla State Med Assoc 87:53-5
Trzepacz, P T; Tarter, R E; Shah, A et al. (1994) SPECT scan and cognitive findings in subclinical hepatic encephalopathy. J Neuropsychiatry Clin Neurosci 6:170-5
Kahn, D; Gavaler, J S; Makowka, L et al. (1993) Gender of donor influences outcome after orthotopic liver transplantation in adults. Dig Dis Sci 38:1485-8
Van Thiel, D H; Dindzans, V J; Schade, R R et al. (1993) Prophylactic versus emergency sclerotherapy of large esophageal varices prior to liver transplantation. Dig Dis Sci 38:1505-10
Tarter, R E; Switala, J; Plail, J et al. (1992) Severity of hepatic encephalopathy before liver transplantation is associated with quality of life after transplantation. Arch Intern Med 152:2097-101
Stauber, R E; Mochizuki, T; Van Thiel, D H et al. (1992) The use of quantitative scintigraphy in the measurement of portal-systemic shunting in rats. Ann Nucl Med 6:209-14

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