Abstract

Although there has been considerable research on the effects of prenatal alcohol consumption on offspring, few studies have carried this assessment beyond the neonatal period. Relatively little is known about the long-term effect of prenatal exposure to alcohol on child development. This proposal represents a unique opportunity to explore this relationship in a cohort of women and their children who currently are being studied during pregnancy and through the eighth postpartum month. We propose to extend the study of this cohort to assess the children at 18 months and 3 years of age. Growth parameters, morphological characteristics and neurological status will be assessed at each time point. Developmental status and behavioral characteristics will be measured using age-appropriate instruments. The study will: (1) Assess the physical development and morphological characteristics of children whose mothers drank heavily during pregnancy compared to those whose mothers drank infrequently or not at all. (2) Examine the developmental status and behavioral characteristics of these children at 18 months and 3 years. (3) Determine differences in electroencephalographic patterns and sleep organization in these children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA006666-03
Application #
3109953
Study Section
(SRC)
Project Start
1985-05-01
Project End
1989-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

De Genna, Natacha Marie; Goldschmidt, Lidush; Day, Nancy L et al. (2017) Maternal trajectories of cigarette use as a function of maternal age and race. Addict Behav 65:33-39
Pugh, Sarah J; Hutcheon, Jennifer A; Richardson, Gale A et al. (2016) Child academic achievement in association with pre-pregnancy obesity and gestational weight gain. J Epidemiol Community Health 70:534-40
Pugh, S J; Hutcheon, J A; Richardson, G A et al. (2016) Gestational weight gain, prepregnancy body mass index and offspring attention-deficit hyperactivity disorder symptoms and behaviour at age 10. BJOG 123:2094-2103
Sonon, Kristen; Richardson, Gale A; Cornelius, Jack et al. (2016) Developmental pathways from prenatal marijuana exposure to Cannabis Use Disorder in young adulthood. Neurotoxicol Teratol 58:46-52
Goldschmidt, Lidush; Richardson, Gale A; Larkby, Cynthia et al. (2016) Early marijuana initiation: The link between prenatal marijuana exposure, early childhood behavior, and negative adult roles. Neurotoxicol Teratol 58:40-45
De Genna, Natacha M; Goldschmidt, Lidush; Day, Nancy L et al. (2016) Prenatal and Postnatal Maternal Trajectories of Cigarette Use Predict Adolescent Cigarette Use. Nicotine Tob Res 18:988-92
Diesel, Jill C; Bodnar, Lisa M; Day, Nancy L et al. (2016) Childhood maltreatment and the risk of pre-pregnancy obesity and excessive gestational weight gain. Matern Child Nutr 12:558-68
Pugh, Sarah J; Richardson, Gale A; Hutcheon, Jennifer A et al. (2015) Maternal Obesity and Excessive Gestational Weight Gain Are Associated with Components of Child Cognition. J Nutr 145:2562-9
De Genna, Natacha M; Cornelius, Marie D; Goldschmidt, Lidush et al. (2015) Maternal age and trajectories of cannabis use. Drug Alcohol Depend 156:199-206
Diesel, J C; Eckhardt, C L; Day, N L et al. (2015) Gestational weight gain and the risk of offspring obesity at 10 and 16 years: a prospective cohort study in low-income women. BJOG 122:1395-402

Showing the most recent 10 out of 54 publications