Abstract

In this prospective epidemiological study, 650 women who represented the entire spectrum of drinking practices were interviewed in their fourth and seventh months of pregnancy. These women and their offspring were assessed at delivery and at 8, 18 and 36 months. The next phase of this study will assess growth, morphological anomalies, cognitive development, behavior, motor skills, and neuropsychological performance of the children at age 6. We have demonstrated a relationship between prenatal alcohol exposure and growth, morphological abnormalities, and cognitive development of the offspring through the age of 3. Continuation of this project will enable us to determine whether the observed relationship between prenatal alcohol use and smaller size and slower rate of growth is maintained as the children mature, and how environmental factors affect this process. It will allow us to evaluate further the effect of prenatal exposure on cognitive development as the children acquire new and more complex skills. The long term impact of prenatal alcohol exposure on the growth and development of the offspring is unknown. We do not know whether prenatal exposure effects in young children persist, resolve, or are expressed differently at older ages. In the absence of this information, we cannot counsel parents or intervene to identify and treat the problems of school- aged children who have been exposed to alcohol prenatally.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
2R01AA006666-06
Application #
3109950
Study Section
Clinical and Treatment Subcommittee (ALCP)
Project Start
1985-05-01
Project End
1993-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
6
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

De Genna, Natacha Marie; Goldschmidt, Lidush; Day, Nancy L et al. (2017) Maternal trajectories of cigarette use as a function of maternal age and race. Addict Behav 65:33-39
Pugh, Sarah J; Hutcheon, Jennifer A; Richardson, Gale A et al. (2016) Child academic achievement in association with pre-pregnancy obesity and gestational weight gain. J Epidemiol Community Health 70:534-40
Pugh, S J; Hutcheon, J A; Richardson, G A et al. (2016) Gestational weight gain, prepregnancy body mass index and offspring attention-deficit hyperactivity disorder symptoms and behaviour at age 10. BJOG 123:2094-2103
Sonon, Kristen; Richardson, Gale A; Cornelius, Jack et al. (2016) Developmental pathways from prenatal marijuana exposure to Cannabis Use Disorder in young adulthood. Neurotoxicol Teratol 58:46-52
Goldschmidt, Lidush; Richardson, Gale A; Larkby, Cynthia et al. (2016) Early marijuana initiation: The link between prenatal marijuana exposure, early childhood behavior, and negative adult roles. Neurotoxicol Teratol 58:40-45
De Genna, Natacha M; Goldschmidt, Lidush; Day, Nancy L et al. (2016) Prenatal and Postnatal Maternal Trajectories of Cigarette Use Predict Adolescent Cigarette Use. Nicotine Tob Res 18:988-92
Diesel, Jill C; Bodnar, Lisa M; Day, Nancy L et al. (2016) Childhood maltreatment and the risk of pre-pregnancy obesity and excessive gestational weight gain. Matern Child Nutr 12:558-68
Pugh, Sarah J; Richardson, Gale A; Hutcheon, Jennifer A et al. (2015) Maternal Obesity and Excessive Gestational Weight Gain Are Associated with Components of Child Cognition. J Nutr 145:2562-9
De Genna, Natacha M; Cornelius, Marie D; Goldschmidt, Lidush et al. (2015) Maternal age and trajectories of cannabis use. Drug Alcohol Depend 156:199-206
Diesel, J C; Eckhardt, C L; Day, N L et al. (2015) Gestational weight gain and the risk of offspring obesity at 10 and 16 years: a prospective cohort study in low-income women. BJOG 122:1395-402

Showing the most recent 10 out of 54 publications