Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA007842-07
Application #
2044176
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Type
Organized Research Units
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Savas, Uzen; Machemer, Daniel E W; Hsu, Mei-Hui et al. (2009) Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem 284:16541-52
Hirani, Vandana; Yarovoy, Anton; Kozeska, Anita et al. (2008) Expression of CYP4F2 in human liver and kidney: assessment using targeted peptide antibodies. Arch Biochem Biophys 478:59-68
Dhar, Madhurima; Sepkovic, Daniel W; Hirani, Vandana et al. (2008) Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11. J Lipid Res 49:612-24
Raucy, Judy L; Lasker, Jerome; Ozaki, Kazuaki et al. (2004) Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes. Toxicol Sci 79:233-41
Hirani, Vandana N; Raucy, Judy L; Lasker, Jerome M (2004) Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19. Drug Metab Dispos 32:1462-7
Raucy, Judy L; Mueller, Lisa; Duan, Kui et al. (2002) Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes. J Pharmacol Exp Ther 302:475-82
Lasker, J M; Chen, W B; Wolf, I et al. (2000) Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. J Biol Chem 275:4118-26
Cummings, B S; Lasker, J M; Lash, L H (2000) Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney. J Pharmacol Exp Ther 293:677-85
Wester, M R; Lasker, J M; Johnson, E F et al. (2000) CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes. Drug Metab Dispos 28:354-9
Pan-Zhou, X R; Cretton-Scott, E; Zhou, X J et al. (1998) Role of human liver P450s and cytochrome b5 in the reductive metabolism of 3'-azido-3'-deoxythymidine (AZT) to 3'-amino-3'-deoxythymidine. Biochem Pharmacol 55:757-66

Showing the most recent 10 out of 26 publications