Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
3R01AA008149-02S1
Application #
3112110
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1990-05-21
Project End
1992-08-31
Budget Start
1990-05-21
Budget End
1990-08-31
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
George Washington University
Department
Type
Schools of Medicine
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20052
Gong, Maokai; Castillo, Leslie; Redman, Robert S et al. (2008) Down-regulation of liver Galbeta1, 4GlcNAc alpha2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans. Metabolism 57:1663-8
Gong, Maokai; Garige, Mamatha; Hirsch, Kenneth et al. (2007) Liver Galbeta1,4GlcNAc alpha2,6-sialyltransferase is down-regulated in human alcoholics: possible cause for the appearance of asialoconjugates. Metabolism 56:1241-7
Marmillot, Philippe; Patel, Sanket; Lakshman, M Raj (2007) Reverse cholesterol transport is regulated by varying fatty acyl chain saturation and sphingomyelin content in reconstituted high-density lipoproteins. Metabolism 56:251-9
Marmillot, Philippe; Munoz, Jennifer; Patel, Sanket et al. (2007) Long-term ethanol consumption impairs reverse cholesterol transport function of high-density lipoproteins by depleting high-density lipoprotein sphingomyelin both in rats and in humans. Metabolism 56:947-53
Azuine, Magnus A; Patel, Sanket J; Lakshman, M Raj (2006) Effects of chronic ethanol administration on the activities and relative synthetic rates of myelin and synaptosomal plasma membrane-associated sialidase in the rat brain. Neurochem Int 48:67-74
Garige, Mamatha; Azuine, Magnus A; Lakshman, M Raj (2006) Chronic ethanol consumption down-regulates CMP-NeuAc:GM3 alpha 2,8-sialyltransferase (ST8Sia-1) gene in the rat brain. Neurochem Int 49:312-8
Garige, Mamatha; Gong, Maokai; Lakshman, M Raj (2006) Ethanol destabilizes liver Gal beta l, 4GlcNAc alpha2,6-sialyltransferase, mRNA by depleting a 3'-untranslated region-specific binding protein. J Pharmacol Exp Ther 318:1076-82
Garige, Mamatha; Azuine, Magnus A; Lakshman, M Raj (2006) Chronic ethanol consumption upregulates the cytosolic and plasma membrane sialidase genes, but down regulates lysosomal membrane sialidase gene in rat liver. Metabolism 55:803-10
Azuine, Magnus A; Patel, Sanket J; Lakshman, M Raj (2005) Chronic ethanol feeding controls the activities of various sialidases by regulating their relative synthetic rates in the rat liver. Metabolism 54:1056-64
Garige, Mamatha; Gong, Maokai; Rao, Manjunath N et al. (2005) Mechanism of action of ethanol in the down-regulation of Gal(beta)1, 4GlcNAc alpha2,6-sialyltransferase messenger RNA in human liver cell lines. Metabolism 54:729-34

Showing the most recent 10 out of 18 publications