Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
3R01AA008990-04S1
Application #
2045015
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1995-08-01
Project End
1998-03-31
Budget Start
1995-08-01
Budget End
1996-03-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Agouron Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Yueh, Mei-Fei; Kawahara, Marleen; Raucy, Judy (2005) Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes. Toxicol In Vitro 19:275-87
Raucy, Judy L; Lasker, Jerome; Ozaki, Kazuaki et al. (2004) Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes. Toxicol Sci 79:233-41
Raucy, Judy L (2003) Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products. Drug Metab Dispos 31:533-9
Allen, S W; Mueller, L; Williams, S N et al. (2001) The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. Drug Metab Dispos 29:1074-9
Raucy, J L; Schultz, E D; Kearins, M C et al. (1999) CYP2E1 expression in human lymphocytes from various ethnic populations. Alcohol Clin Exp Res 23:1868-74
Palmer, C N; Hsu, M H; Griffin, K J et al. (1998) Peroxisome proliferator activated receptor-alpha expression in human liver. Mol Pharmacol 53:14-22
Raucy, J L; Schultz, E D; Wester, M R et al. (1997) Human lymphocyte cytochrome P450 2E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity. Drug Metab Dispos 25:1429-35
Carpenter, S P; Savage, D D; Schultz, E D et al. (1997) Ethanol-mediated transplacental induction of CYP2E1 in fetal rat liver. J Pharmacol Exp Ther 282:1028-36
Carpenter, S P; Lasker, J M; Raucy, J L (1996) Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes. Mol Pharmacol 49:260-8
Raucy, J L (1995) Risk assessment: toxicity from chemical exposure resulting from enhanced expression of CYP2E1. Toxicology 105:217-24

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