Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA009384-04
Application #
2045621
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1992-08-01
Project End
1997-03-31
Budget Start
1995-08-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Nebraska Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198

  Publications

Curry-McCoy, Tiana V; Osna, Natalia A; Nanji, Amin A et al. (2010) Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient mice. Alcohol Clin Exp Res 34:251-61
Curry-McCoy, Tiana V; Osna, Natalia A; Donohue Jr, Terrence M (2009) Modulation of lysozyme function and degradation after nitration with peroxynitrite. Biochim Biophys Acta 1790:778-86
Osna, Natalia A; White, Ronda L; Krutik, Viatcheslav M et al. (2008) Proteasome activation by hepatitis C core protein is reversed by ethanol-induced oxidative stress. Gastroenterology 134:2144-52
Donohue, Terrence M; Curry-McCoy, Tiana V; Nanji, Amin A et al. (2007) Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats. Alcohol Clin Exp Res 31:1944-52
Donohue Jr, Terrence M; Curry-McCoy, Tiana V; Todero, Sandra L et al. (2007) L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury. Alcohol Clin Exp Res 31:1053-60
Osna, Natalia A; Clemens, Dahn L; Donohue Jr, Terrence M (2005) Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells. Hepatology 42:1109-17
Donohue Jr, Terrence M; Kharbanda, Kusum K; Casey, Carol A et al. (2004) Decreased proteasome activity is associated with increased severity of liver pathology and oxidative stress in experimental alcoholic liver disease. Alcohol Clin Exp Res 28:1257-63
Osna, Natalia A; Haorah, James; Krutik, Viatcheslav M et al. (2004) Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo. Hepatology 40:574-82
Donohue Jr, Terrence M; Osna, Natalia A (2003) Intracellular proteolytic systems in alcohol-induced tissue injury. Alcohol Res Health 27:317-24
Haorah, James; MacDonald, Richard G; Stoner, Julie A et al. (2003) Ethanol consumption decreases the synthesis of the mannose 6-phosphate/insulin-like growth factor II receptor but does not decrease its messenger RNA. Biochem Pharmacol 65:637-48

Showing the most recent 10 out of 19 publications