The scientific issues of this project are focused around four core developmental phenomena of the 18-23 year old period: 1) this period is normatively the highest alcohol consumption interval in the life course;2) toward the end of this interval, for the majority of young adults, a decrease in consumption begins to take place;3) for a higher risk subset of the population, the high consumption pattern continues;and 4) while these critical behavioral shifts are occurring, the neural networks responsible for effortful control and reward response/incentive reactivity are also maturing, albeit at different rates. Three corollary, as yet unanswered questions critical to both social policy about youthful drinking and intervention, are to be addressed: A) To what degree are the changes in drinking behavior taking place over this developmental interval attributable to the maturation of these neural networks?;B) Does heavy alcohol consumption influence the maturation of these networks?;C) How do social environmental reinforcers and prior individual differences in risk mediate or moderate both of these outcomes? During the past 5 years, this project has investigated neurocognitive and functional brain indicators of later problem alcohol use, identifying trajectories of problem use and neural indicators of risk and resilience. This revised continuation project builds on this prior work by extending the investigation into early adulthood and identifying effects of heavy drinking on personality, neurocognition and brain function as well as the interactions between early risk, heavy drinking, and social context (social supports, peer drinking, environmental insults) throughout adolescence and early adulthood. Subjects are participants in the Michigan Longitudinal Study, a high risk for alcohol use disorder family study that has been characterizing temperament, behavioral risk and social context since early childhood and neurocognitive risk since early adolescence. Associated brain function has been studied using fMRI since late adolescence in a subset of these participants. Over the next 5 years, the study will probe the two domains of Effortful Control, and Incentive Reactivity, assessed at the levels of brain function (Regulation/dysregulation of frontostriatal and frontolimbic circuitry and connectivity), neurocognition, and personality. Neurocognitive and personality assessments will continue at 3 year intervals (N= 1456), starting at age 12;a subset of participants (N = 225) will continue to be assessed yearly via fMRI starting at age 18. An important new focus of the imaging work is the interaction between frontal and subcortical processes, to be explored longitudinally using a delayed discounting task, and frontostriatal and frontolimbic functional connectivity analyses. Results will developmentally characterize the relationship between drinking behavior, social environment, and brain function and connectivity change. A special focus is the extent to which drinking behavior lags brain change or leads it, and the role that social environment plays in moderating such change.
This project is likely to promote a more in-depth understanding about the intermediate neural pathways underlying susceptibility to heavy drinking and alcohol use disorder at an age interval when both of these phenomena reach their peak. Results will provide new knowledge of how temperament, behavior, brain networks and social environmental risk interact, influencing stability and change in drinking behavior and brain functional networks at arguably the most critical developmental period for alcohol use in the lifespan. Findings will have implications for early identification, prevention, and early treatment of at risk individuals, as well as those in the early stages of an alcohol abusing career.
|Wong, Maria M; Puttler, Leon I; Nigg, Joel T et al. (2018) Sleep and behavioral control in earlier life predicted resilience in young adulthood: A prospective study of children of alcoholics and controls. Addict Behav 82:65-71|
|Martz, Meghan E; Zucker, Robert A; Schulenberg, John E et al. (2018) Psychosocial and neural indicators of resilience among youth with a family history of substance use disorder. Drug Alcohol Depend 185:198-206|
|Ip, Ka I; Jester, Jennifer M; Puttler, Leon I et al. (2018) Alcoholic family marital heterogeneity aggregates different child behavior problems both pre- and postseparation. Dev Psychopathol :1-18|
|Meldrum, Ryan Charles; Trucco, Elisa M; Cope, Lora M et al. (2018) Brain Activity, Low Self-Control, and Delinquency: An fMRI Study of At-Risk Adolescents. J Crim Justice 56:107-117|
|Trucco, Elisa M; Cope, Lora M; Burmeister, Margit et al. (2018) Pathways to Youth Behavior: The Role of Genetic, Neural, and Behavioral Markers. J Res Adolesc 28:26-39|
|Trucco, Elisa M; Villafuerte, Sandra; Hussong, Andrea et al. (2018) Biological underpinnings of an internalizing pathway to alcohol, cigarette, and marijuana use. J Abnorm Psychol 127:79-91|
|Hardee, Jillian E; Cope, Lora M; Munier, Emily C et al. (2017) Sex differences in the development of emotion circuitry in adolescents at risk for substance abuse: a longitudinal fMRI study. Soc Cogn Affect Neurosci 12:965-975|
|Cope, Lora M; Munier, Emily C; Trucco, Elisa M et al. (2017) Effects of the serotonin transporter gene, sensitivity of response to alcohol, and parental monitoring on risk for problem alcohol use. Alcohol 59:7-16|
|Nigg, Joel T; Jester, Jennifer M; Stavro, Gillian M et al. (2017) Specificity of executive functioning and processing speed problems in common psychopathology. Neuropsychology 31:448-466|
|Puttler, Leon I; Fitzgerald, Hiram E; Heitzeg, Mary M et al. (2017) BOYS, EARLY RISK FACTORS FOR ALCOHOL PROBLEMS, AND THE DEVELOPMENT OF THE SELF: AN INTERCONNECTED MATRIX. Infant Ment Health J 38:83-96|
Showing the most recent 10 out of 61 publications