This is a competing renewal of Gene-Environment Interaction in Adolescent Alcohol Use (R01AA015416), a new investigator research grant that used data from a longitudinal, population-based Finnish twin study to characterize the extent and nature of gene-environment interactions on substance use and externalizing behavior across adolescence. Our analyses demonstrated that etiological factors impacting substance use and externalizing behavior in adolescence vary profoundly as a function of the environment. In this competing renewal, we propose to use data now available on the twins in the young 20s (range 21-27 years) to characterize gene-environment interplay across the transition to young adulthood. The young 20s is a period of critical change as new environments become developmentally relevant (e.g., romantic partnerships, continuation vs. cessation of education, joining the workforce, having children). It also represents a critical time for the development of risky alcohol use behaviors and the onset of problems. This application, prepared by a team of investigators from Virginia Commonwealth University, the University of Helsinki, and Indiana University, has three specific aims.
The first aim i s to use twin data to characterize gene-environment processes (both gene-environment correlation and interaction) on substance use and externalizing behavior in young adulthood.
The second aim i s to conduct a series of exploratory analyses aimed at understanding how gene-environment interaction effects identified in twin data can inform our understanding of GxE effects associated with measured genes. We will test whether environments that moderate latent genetic risk in the twin analyses also moderate the association between specific individual genotypic risk and outcome.
The third aim i s to test the generalizability of identified gene environment interaction effects in a second, independent sample, the Virginia Twin Study of Adolescent Behavioral Development, with phenotypic data collection across a parallel age range from adolescence to young adulthood, and GWAS data. Together, these analyses will advance our understanding of how genetic and environmental influences come together to contribute to substance use patterns during the high-risk young adulthood developmental phase.

Public Health Relevance

Using both twin and molecular data, this application aims to understand the processes by which genetic and environmental factors impact substance use during the transition to young adulthood. Young adulthood represents a critical period for the development of risky alcohol use behaviors and the onset of problems, and is associated with a number of critical life transitions (e.g., romantic partnerships, continuation vs cessation of education, joining the workforce, having children). Understanding how genetic and environmental factors interact across this important, high-risk period will be critical to develop more effective, tailored programs of prevention and intervention.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Project (R01)
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Behavioral Genetics and Epidemiology Study Section (BGES)
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Scott, Marcia S
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Virginia Commonwealth University
Schools of Medicine
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Korhonen, Tellervo; Sihvola, Elina; Latvala, Antti et al. (2018) Early-onset tobacco use and suicide-related behavior - A prospective study from adolescence to young adulthood. Addict Behav 79:32-38
Dick, Danielle M (2018) Mapping Risk from Genes to Behavior: The Enduring and Evolving Influence of Irving Gottesman's Endophenotype Concept. Twin Res Hum Genet 21:306-309
Dick, Danielle M; Barr, Peter B; Cho, Seung Bin et al. (2018) Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the ""Other"" Next Steps. Genes Brain Behav 17:e12447
Salvatore, Jessica E; Savage, Jeanne E; Barr, Peter et al. (2018) Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems. Alcohol Clin Exp Res 42:413-423
Savage, Jeanne E; Rose, Richard J; Pulkkinen, Lea et al. (2018) Early maturation and substance use across adolescence and young adulthood: A longitudinal study of Finnish twins. Dev Psychopathol 30:79-92
Savage, Jeanne E; Salvatore, Jessica E; Aliev, Fazil et al. (2018) Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. Alcohol Clin Exp Res 42:520-530
Barr, Peter B; Silberg, Judy; Dick, Danielle M et al. (2018) Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk. Soc Sci Med 209:51-58
Dick, Danielle M (2018) Commentary for Special Issue of Prevention Science ""Using Genetics in Prevention: Science Fiction or Science Fact?"" Prev Sci 19:101-108
Salvatore, Jessica E; Dick, Danielle M (2018) Genetic influences on conduct disorder. Neurosci Biobehav Rev 91:91-101
Barr, Peter B; Salvatore, Jessica E; Maes, Hermine H et al. (2017) Social Relationships Moderate Genetic Influences on Heavy Drinking in Young Adulthood. J Stud Alcohol Drugs 78:817-826

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