Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG002467-10S1
Application #
3114455
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1985-02-01
Project End
1995-02-28
Budget Start
1991-03-22
Budget End
1992-02-28
Support Year
10
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Young, Duprane Pedaci; Kushner, Irving; Samols, David (2008) Binding of C/EBPbeta to the C-reactive protein (CRP) promoter in Hep3B cells is associated with transcription of CRP mRNA. J Immunol 181:2420-7
Chakravarty, Kaushik; Hanson, Richard W (2007) Insulin regulation of phosphoenolpyruvate carboxykinase-c gene transcription: the role of sterol regulatory element-binding protein 1c. Nutr Rev 65:S47-56
Cha-Molstad, Hyunjoo; Young, Duprane Pedaci; Kushner, Irving et al. (2007) The interaction of C-Rel with C/EBPbeta enhances C/EBPbeta binding to the C-reactive protein gene promoter. Mol Immunol 44:2933-42
Schwartz, Randall; Osborne-Lawrence, Sherri; Hahner, Lisa et al. (2007) C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice. Circ Res 100:1452-9
Vongpatanasin, Wanpen; Thomas, Gail D; Schwartz, Randall et al. (2007) C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice. Circulation 115:1020-8
Jiang, S; Xia, D; Samols, D (2006) Expression of rabbit C-reactive protein in transgenic mice inhibits development of antigen-induced arthritis. Scand J Rheumatol 35:351-5
Kushner, Irving; Rzewnicki, Debra; Samols, David (2006) What does minor elevation of C-reactive protein signify? Am J Med 119:166.e17-28
Mineo, Chieko; Gormley, Andrew K; Yuhanna, Ivan S et al. (2005) FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase. Circ Res 97:1124-31
Chakravarty, Kaushik; Wu, Shwu-Yuan; Chiang, Cheng-Ming et al. (2004) SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver. J Biol Chem 279:15385-95
Black, Steven; Agrawal, Alok; Samols, David (2003) The phosphocholine and the polycation-binding sites on rabbit C-reactive protein are structurally and functionally distinct. Mol Immunol 39:1045-54

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