Ample evidence supports the assertion that the latency of the P300 component of the human event-related brain potential is proportional to stimulus evaluation and categorization processes and is relatively independent of response selection and execution processes. We shall use P300 latency to gain a more detailed understanding of the ubiquitous slowness of behavior in the aged. This project will be conducted in collaboration with Rush-Presbyterian-ST. Luke's Medical Center in Chicago. Such collaboration will bring together the necessary skills as well as the required subject population in which to develop a battery of psychophysiological tests in which P300 latency can be dissociated from reaction time. Each of these tests will assess the duration of a specific phase or stage of huma information processing. The tests will be administered to young adults in Champaign-Urbana and to the """"""""normal control group"""""""" of aged individuals in the """"""""normal controals"""""""" assembled in the Program Project """"""""Cerebral Decline in Aging"""""""" (3P0-AG-00905) at Rush-Presbyterian Medical School in Chicago. The results should allow us to determine which, if any, of the several stages of information processingis specifically affected by aging.
Gillum, R F; Obisesan, Thomas O (2010) Physical activity, cognitive function, and mortality in a US national cohort. Ann Epidemiol 20:251-7 |
deToledo-Morrell, L; Evers, S; Hoeppner, T J et al. (1991) A 'stress' test for memory dysfunction. Electrophysiologic manifestations of early Alzheimer's disease. Arch Neurol 48:605-9 |
Miller, G A; Bashore, T R; Farwell, L A et al. (1987) Research in geriatric psychophysiology. Annu Rev Gerontol Geriatr 7:1-27 |
Donchin, E; Miller, G A; Farwell, L A (1986) The endogenous components of the event-related potential--a diagnostic tool? Prog Brain Res 70:87-102 |
de Toledo-Morrell, L; Morrell, F (1985) Electrophysiological markers of aging and memory loss in rats. Ann N Y Acad Sci 444:296-311 |