Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG003978-09
Application #
3114894
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1982-08-01
Project End
1991-07-31
Budget Start
1990-08-10
Budget End
1991-07-31
Support Year
9
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Graduate Schools
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Witkowski, J M; Miller, R A (1999) Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein. Mech Ageing Dev 107:165-80
Telford, W G; Miller, R A (1999) Aging increases CD8 T cell apoptosis induced by hyperstimulation but decreases apoptosis induced by agonist withdrawal in mice. Cell Immunol 191:131-8
Dozmorov, I M; Miller, R A (1999) Age-associated decline in responses of naive T cells to in vitro immunization reflects shift in glucocorticoid sensitivity. Life Sci 64:1849-59
Dozmorov, I M; Miller, R A (1998) Generation of antigen-specific Th2 cells from unprimed mice in vitro: effects of dexamethasone and anti-IL-10 antibody. J Immunol 160:2700-5
Mosley, R L; Koker, M M; Miller, R A (1998) Idiosyncratic alterations of TCR size distributions affecting both CD4 and CD8 T cell subsets in aging mice. Cell Immunol 189:10-8
Miller, R A; Garcia, G; Kirk, C J et al. (1997) Early activation defects in T lymphocytes from aged mice. Immunol Rev 160:79-90
Telford, W G; Nam, S Y; Podack, E R et al. (1997) CD30-regulated apoptosis in murine CD8 T cells after cessation of TCR signals. Cell Immunol 182:125-36
Bining, N; Miller, R A (1997) Cytokine production by subsets of CD4 memory T cells differing in P-glycoprotein expression: effects of aging. J Gerontol A Biol Sci Med Sci 52:B137-45
Dozmorov, I; Miller, R A (1997) In vitro production of antigen-specific T cells from unprimed mice: role of dexamethasone and anti-IL-10 antibodies. Cell Immunol 178:187-96
Witkowski, J M; Gorgas, G; Miller, R A (1996) Reciprocal expression of P-glycoprotein and TAP1 accompanied by higher expression of MHC class I antigens in T cells of old mice. J Gerontol A Biol Sci Med Sci 51:B76-82

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