Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG004594-06S1
Application #
3115235
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1984-01-01
Project End
1990-06-30
Budget Start
1990-04-01
Budget End
1990-06-30
Support Year
6
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Bjorkman, S; Wada, D R; Stanski, D R (1998) Application of physiologic models to predict the influence of changes in body composition and blood flows on the pharmacokinetics of fentanyl and alfentanil in patients. Anesthesiology 88:657-67
Wada, D R; Bjorkman, S; Ebling, W F et al. (1997) Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans. Anesthesiology 87:884-99
Harashima, H; Ebling, W F; Wada, D R et al. (1997) No effect of age on the dose requirement of thiopental in the rat. Exp Gerontol 32:315-24
Wada, D R; Harashima, H; Ebling, W et al. (1996) Effects of thiopental on regional blood flows in the rat. Anesthesiology 84:596-604
MacIver, M B; Mandema, J W; Stanski, D R et al. (1996) Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity. Anesthesiology 84:1411-24
Wada, D R; Stanski, D R; Ebling, W F (1995) A PC-based graphical simulator for physiological pharmacokinetic models. Comput Methods Programs Biomed 46:245-55
Bjorkman, S; Wada, D R; Stanski, D R et al. (1994) Comparative physiological pharmacokinetics of fentanyl and alfentanil in rats and humans based on parametric single-tissue models. J Pharmacokinet Biopharm 22:381-410
Burm, A G; Ausems, M E; Spierdijk, J et al. (1993) Pharmacokinetics of alfentanil administered at a variable rate during three types of surgery. Eur J Anaesthesiol 10:241-51
Bjorkman, S; Stanski, D R; Harashima, H et al. (1993) Tissue distribution of fentanyl and alfentanil in the rat cannot be described by a blood flow limited model. J Pharmacokinet Biopharm 21:255-79
Verotta, D; Sheiner, L B (1991) Semiparametric analysis of non-steady-state pharmacodynamic data. J Pharmacokinet Biopharm 19:691-712

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