Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG005214-11
Application #
2049000
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1985-02-01
Project End
1998-03-31
Budget Start
1996-02-25
Budget End
1996-03-31
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Shivnaraine, Rabindra V; Kelly, Brendan; Sankar, Krishana S et al. (2016) Allosteric modulation in monomers and oligomers of a G protein-coupled receptor. Elife 5:
Redka, Dar'ya S; Morizumi, Takefumi; Elmslie, Gwendolynne et al. (2014) Coupling of g proteins to reconstituted monomers and tetramers of the M2 muscarinic receptor. J Biol Chem 289:24347-65
Shivnaraine, Rabindra V; Huang, Xi-Ping; Seidenberg, Margaret et al. (2012) Heterotropic cooperativity within and between protomers of an oligomeric M(2) muscarinic receptor. Biochemistry 51:4518-40
Stahl, Edward; Elmslie, Gwendolynne; Ellis, John (2011) Allosteric modulation of the M? muscarinic receptor by amiodarone and N-ethylamiodarone: application of the four-ligand allosteric two-state model. Mol Pharmacol 80:378-88
Stahl, Edward; Ellis, John (2010) Novel allosteric effects of amiodarone at the muscarinic M5 receptor. J Pharmacol Exp Ther 334:214-22
Prilla, Stefanie; Schrobang, Jasmin; Ellis, John et al. (2006) Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity. Mol Pharmacol 70:181-93
Huang, Xi-Ping; Prilla, Stefanie; Mohr, Klaus et al. (2005) Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3-phtha Mol Pharmacol 68:769-78
Trankle, Christian; Dittmann, Andreas; Schulz, Uwe et al. (2005) Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors. Mol Pharmacol 68:1597-610
Voigtlander, Uta; Johren, Kirstin; Mohr, Marion et al. (2003) Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupie Mol Pharmacol 64:21-31
Ford, Diane J; Essex, Anthony; Spalding, Tracy A et al. (2002) Homologous mutations near the junction of the sixth transmembrane domain and the third extracellular loop lead to constitutive activity and enhanced agonist affinity at all muscarinic receptor subtypes. J Pharmacol Exp Ther 300:810-7

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