The Study of Osteoporotic Fractures (SOF) is a multi-center longitudinal study in a cohort of 9,704 older women. SOF has comprehensive data about risk factors for osteoporosis and other diseases, along with an archive of serum, buffy coat and urine specimens. Data from SOF have served for: (1) developing osteoporosis guidelines, (2) estimating the cost-effectiveness of screening for osteoporosis, and (3) planning trials of osteoporosis therapies. They propose to renew SOF to sustain this unique resource and to pursue several new hypotheses. Osteoporosis is a chronic disease and prevention of fractures must be considered over the very long-term, not just the 3-5 year duration of most studies in the field. As the study of osteoporosis and aging with the longest (nearly 15 years) follow-up, SOF will provide the foundation for describing ways to identify people at greatest risk of osteoporosis and fractures decades in advance. They envision a new generation of clinical guidelines based on long-term prediction of risk of fractures and disability. Because they have enriched the cohort with African-American women, SOF will also provide unique information on risk factors for osteoporosis and non-spine fractures in older African American women. SOF was the first study to show a link between low BMD and risk of stroke and this has helped to fuel the interest and new investigations about the links between arterial calcification and osteoporosis. If they demonstrate, and can begin to explain, the link between these two diseases, this may lead to screening tools and treatments that simultaneously decrease the risk of both of these disabling conditions. Preliminary results from SOF suggest that impaired sleep may be a major cause of fractures, disability and decline in cognition in older women. If the next phase of SOF confirms these relationships using more objective measures of insomnia and other sleep disorders, then this might change current clinical policies and practices toward more aggressive screening and better coverage for treatment of sleep disorders. Finally, the value of SOF could be magnified by recruiting other scientists to work on SOF data and samples. They propose to make the database easily accessible to investigators outside of SOF and assist them in making productive use of a database that represents one of the most comprehensive prospective sources of information about the health of older women.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
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Special Emphasis Panel (ZAR1-JRL-B (M1))
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Sherman, Sherry
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University of Minnesota Twin Cities
Public Health & Prev Medicine
Schools of Public Health
United States
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Woods, Gina N; Huang, Mei-Hua; Cawthon, Peggy M et al. (2018) Patterns of menopausal hormone therapy use and hyperkyphosis in older women. Menopause 25:738-743
Suri, Pradeep; Palmer, Melody R; Tsepilov, Yakov A et al. (2018) Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain. PLoS Genet 14:e1007601
Eurelings, Lisa Sm; van Dalen, Jan Willem; Ter Riet, Gerben et al. (2018) Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data. Clin Epidemiol 10:363-379
Bonham, Luke W; Evans, Daniel S; Liu, Yongmei et al. (2018) Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. Am J Alzheimers Dis Other Demen 33:153-165
Diem, Susan J; Vo, Tien N; Langsetmo, Lisa et al. (2018) Impact of Competing Risk of Mortality on Association of Cognitive Impairment With Risk of Hip Fracture in Older Women. J Bone Miner Res 33:1595-1602
Ensrud, Kristine E; Kats, Allyson M; Schousboe, John T et al. (2018) Frailty Phenotype and Healthcare Costs and Utilization in Older Women. J Am Geriatr Soc 66:1276-1283
Black, Dennis M; Cauley, Jane A; Wagman, Rachel et al. (2018) The Ability of a Single BMD and Fracture History Assessment to Predict Fracture Over 25 Years in Postmenopausal Women: The Study of Osteoporotic Fractures. J Bone Miner Res 33:389-395
Mariani, Sara; Tarokh, Leila; Djonlagic, Ina et al. (2018) Evaluation of an automated pipeline for large-scale EEG spectral analysis: the National Sleep Research Resource. Sleep Med 47:126-136
LeBlanc, Erin S; Rizzo, Joanne H; Pedula, Kathryn L et al. (2018) Long-Term Weight Trajectory and Risk of Hip Fracture, Falls, Impaired Physical Function, and Death. J Am Geriatr Soc 66:1972-1979
Byers, Amy L; Lui, Li-Yung; Vittinghoff, Eric et al. (2018) Burden of Depressive Symptoms Over 2 Decades and Risk of Nursing Home Placement in Older Women. J Am Geriatr Soc 66:1895-1901

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