Fractures of the hip and wrist are a common, costly and preventable threat to the health and survival of the elderly. A better understanding of the risk factors for hip and Colles' fractures will add to our knowledge about their etiology, and help focus research and preventative efforts on those who are at greatest risk. We propose to characterize risk factors for hip and Colles' fractures in a multicenter prospective study of 9,600 elderly women followed quarterly for an average of 3.5 years. Our cohort will be a population-based sample of non-black women aged 65 or greater who are screened from 1986 thru 1988 at clinical centers in Pittsburgh, Portland, Maryland and Minneapolis. At the baseline exam, we will measure a large set of potential historical and clinical predictors of fractures. We will also use single-photon absorptiometry of the radius and x-ray the hand, spine and hips to determine whether simple radiographic measurements can identify those with the greatest risk of fracture. We will also freeze serum from all participants at the outset and test the stability of hormone measurements on a subsample after storage at -l96 degrees C for several years; measurements that are shown to be stable will be the subject of a future study of the hormonal differences between women in our cohort who suffer fractures and those who do not. We conservatively estimate that 165 hip and 150 Colles' fractures will occur, yielding a power of .90 to detect risk ratios of less than 2.0 common risk factors. Our prospective design will yield more information with fewer potential biases than previous (retrospective) studies on this topic, and our nested-case control analyses will minimize the costs of the expensive endocrinologic and radiologic measurements. The study cohort, and its bank of sera, x-rays and clinical data will be an excellent resource for future studies of osteoporosis, fractures and other diseases of the elderly. The results of our study will guide clinical and public health efforts to prevent these fractures.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
Project #
Application #
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
Schools of Medicine
San Francisco
United States
Zip Code
Eurelings, Lisa Sm; van Dalen, Jan Willem; Ter Riet, Gerben et al. (2018) Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data. Clin Epidemiol 10:363-379
Bonham, Luke W; Evans, Daniel S; Liu, Yongmei et al. (2018) Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. Am J Alzheimers Dis Other Demen 33:153-165
Diem, Susan J; Vo, Tien N; Langsetmo, Lisa et al. (2018) Impact of Competing Risk of Mortality on Association of Cognitive Impairment With Risk of Hip Fracture in Older Women. J Bone Miner Res 33:1595-1602
Ensrud, Kristine E; Kats, Allyson M; Schousboe, John T et al. (2018) Frailty Phenotype and Healthcare Costs and Utilization in Older Women. J Am Geriatr Soc 66:1276-1283
Black, Dennis M; Cauley, Jane A; Wagman, Rachel et al. (2018) The Ability of a Single BMD and Fracture History Assessment to Predict Fracture Over 25 Years in Postmenopausal Women: The Study of Osteoporotic Fractures. J Bone Miner Res 33:389-395
Mariani, Sara; Tarokh, Leila; Djonlagic, Ina et al. (2018) Evaluation of an automated pipeline for large-scale EEG spectral analysis: the National Sleep Research Resource. Sleep Med 47:126-136
LeBlanc, Erin S; Rizzo, Joanne H; Pedula, Kathryn L et al. (2018) Long-Term Weight Trajectory and Risk of Hip Fracture, Falls, Impaired Physical Function, and Death. J Am Geriatr Soc 66:1972-1979
Byers, Amy L; Lui, Li-Yung; Vittinghoff, Eric et al. (2018) Burden of Depressive Symptoms Over 2 Decades and Risk of Nursing Home Placement in Older Women. J Am Geriatr Soc 66:1895-1901
Sun, Jianping; Oualkacha, Karim; Forgetta, Vincenzo et al. (2018) Exome-wide rare variant analyses of two bone mineral density phenotypes: the challenges of analyzing rare genetic variation. Sci Rep 8:220
Ward, Michael E; Gelfand, Jeffrey M; Lui, Li-Yung et al. (2018) Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment. Ann Neurol 83:730-738

Showing the most recent 10 out of 259 publications